Journal ArticleDOI
Intrinsic peroxidase-like activity of ferromagnetic nanoparticles
Lizeng Gao,Jie Zhuang,Leng Nie,Jinbin Zhang,Yu Zhang,Ning Gu,Taihong Wang,Jing Feng,Dongling Yang,Sarah Perrett,Xiyun Yan +10 more
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TLDR
It is reported that magnetite nanoparticles in fact possess an intrinsic enzyme mimetic activity similar to that found in natural peroxidases, which are widely used to oxidize organic substrates in the treatment of wastewater or as detection tools.Abstract:
Nanoparticles containing magnetic materials, such as magnetite (Fe3O4), are particularly useful for imaging and separation techniques. As these nanoparticles are generally considered to be biologically and chemically inert, they are typically coated with metal catalysts, antibodies or enzymes to increase their functionality as separation agents. Here, we report that magnetite nanoparticles in fact possess an intrinsic enzyme mimetic activity similar to that found in natural peroxidases, which are widely used to oxidize organic substrates in the treatment of wastewater or as detection tools. Based on this finding, we have developed a novel immunoassay in which antibody-modified magnetite nanoparticles provide three functions: capture, separation and detection. The stability, ease of production and versatility of these nanoparticles makes them a powerful tool for a wide range of potential applications in medicine, biotechnology and environmental chemistry.read more
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Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes
Hui Wei,Erkang Wang +1 more
TL;DR: This review discusses various nanomaterials that have been explored to mimic different kinds of enzymes and covers their kinetics, mechanisms and applications in numerous fields, from biosensing and immunoassays, to stem cell growth and pollutant removal.
Journal ArticleDOI
Graphene oxide: intrinsic peroxidase catalytic activity and its application to glucose detection.
TL;DR: A simple, cheap, and highly sensitive and selective colorimetric method for glucose detection has been developed and will facilitate the utilization of GO-COOH intrinsic peroxidase activity in medical diagnostics and biotechnology.
Journal ArticleDOI
Nanozymes: Classification, Catalytic Mechanisms, Activity Regulation, and Applications
TL;DR: This review systematically introduces the classification, catalytic mechanism, activity regulation as well as recent research progress of nanozymes in the field of biosensing, environmental protection, and disease treatments, etc. in the past years.
Journal ArticleDOI
Magnetically recoverable nanocatalysts.
TL;DR: This Review concludes with a conclusion that further research is needed into the determinants of infectious disease and the immune system in order to treat these diseases and provide effective treatments.
Journal ArticleDOI
Zirconium-Metalloporphyrin PCN-222: Mesoporous Metal–Organic Frameworks with Ultrahigh Stability as Biomimetic Catalysts†
TL;DR: A unique strategy employing heme-like active centers as structural motifs for the assembly of highly stable porous materials, which should possess well-defined mesochannels and ultrahigh stability in aqueous solution is proposed.
References
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Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance
Leon R. Hirsch,R.J. Stafford,James A. Bankson,S.R. Sershen,Belinda Rivera,Roger E. Price,John D. Hazle,Nancy J. Halas,Jennifer L. West +8 more
TL;DR: In vivo studies under magnetic resonance guidance revealed that exposure to low doses of NIR light in solid tumors treated with metal nanoshells reached average maximum temperatures capable of inducing irreversible tissue damage, and found good correlation with histological findings.
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Monodisperse magnetic single-crystal ferrite microspheres.
TL;DR: This work reports a general approach for the fabrication of monodisperse, hydrophilic, and single-crystalline ferrite microspheres by a solvothermal reduction method, and is the first report on the synthesis of single- Crystalline magneticmicrospheres.
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Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy
I. Jolanda M. de Vries,W. Joost Lesterhuis,Jelle O. Barentsz,Pauline Verdijk,J. Han van Krieken,Otto C. Boerman,Wim J.G. Oyen,Johannes J. Bonenkamp,Jan B.M. Boezeman,Gosse J. Adema,Jeff W.M. Bulte,Tom W. J. Scheenen,Cornelis J. A. Punt,Arend Heerschap,Carl G. Figdor +14 more
TL;DR: In vivo magnetic resonance tracking of magnetically labeled cells is feasible in humans for detecting very low numbers of dendritic cells in conjunction with detailed anatomical information and appears clinically safe and well suited to monitor cellular therapy in humans.
Journal ArticleDOI
Magnetically Recoverable Chiral Catalysts Immobilized on Magnetite Nanoparticles for Asymmetric Hydrogenation of Aromatic Ketones
TL;DR: Orthogonal nature of the present catalyst immobilization approach should allow the design of other superparamagnetic nanoparticle-supported asymmetric catalysts for a wide range of organic transformations.
Journal ArticleDOI
Magnetic techniques for the isolation and purification of proteins and peptides
TL;DR: Various methodologies, strategies and materials which can be used for the isolation and purification of target proteins and peptides with the help of magnetic field are summarized.
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