Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm.
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...Moreover, a disorder-order transition induced in “natively unfolded” proteins during the binding of specific targets in vivo might represent a simple mechanism for regulation of numerous cellular processes, including transcriptional and translational regulation and cell cycle control.(29) Evolutionary persistence of the “natively unfolded” proteins represents additional confirmation of their importance and raises intriguing questions on the role of protein disorders in biologic processes....
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...It has been suggested that the lack of rigid globular structure under physiologic conditions might represent a considerable functional advantage for “natively unfolded” proteins, as their large plasticity allows them to interact efficiently with several different targets.(29) Moreover, a disorder-order transition induced in “natively unfolded” proteins during the binding of specific targets in vivo might represent a simple mechanism for regulation of numerous cellular processes, including transcriptional and translational regulation and cell cycle control....
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"Intrinsically unstructured proteins..." refers background in this paper
...In addition, there are HAT and bromodomains associated with chromatin remodeling (Ogryzko et al., 1996; Jeanmougin et al., 1997) and putative PHD and ZZ zinc ®nger domains of unknown function (Aasland et al....
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...In addition, there are HAT and bromodomains associated with chromatin remodeling (Ogryzko et al., 1996; Jeanmougin et al., 1997) and putative PHD and ZZ zinc ®nger domains of unknown function (Aasland et al., 1995; Ponting et al., 1996)....
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"Intrinsically unstructured proteins..." refers background in this paper
...…domain includes the LXXLL motif that has been directly implicated in nuclear receptor binding (Torchia et al., 1997; Heery et al., 1997), and which has been shown, for other coactivators, to form an a-helix upon complex formation (Nolte et al., 1998; Darimont et al., 1998; Shiau et al., 1998)....
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..., 1997), and which has been shown, for other coactivators, to form an a-helix upon complex formation (Nolte et al., 1998; Darimont et al., 1998; Shiau et al., 1998)....
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2,381 citations
"Intrinsically unstructured proteins..." refers background in this paper
...An X-ray structure has been determined for the core synaptic SNARE complex formed by syntaxin-1A, synaptobrevin-II, and SNAP-25B; the ternary complex consists of a twisted four-helix bundle 120 AÊ in length (Sutton et al., 1998)....
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"Intrinsically unstructured proteins..." refers background in this paper
...…receptor interaction domain includes the LXXLL motif that has been directly implicated in nuclear receptor binding (Torchia et al., 1997; Heery et al., 1997), and which has been shown, for other coactivators, to form an a-helix upon complex formation (Nolte et al., 1998; Darimont et…...
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...The unstructured receptor interaction domain includes the LXXLL motif that has been directly implicated in nuclear receptor binding (Torchia et al., 1997; Heery et al., 1997), and which has been shown, for other coactivators, to form an a-helix upon complex formation (Nolte et al....
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