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Introduction, phytochemistry, traditional uses and biological activity of genus Piper: a review

01 May 2011-Vol. 2, Iss: 2, pp 130-144
TL;DR: Piper, the pepper plants or pepper vines are an economically and ecologically important genus in the family Piperaceae, which contains about 1,000-2,000 species of shrubs, herbs, and lianas, many of which are keystone species in their native habitat.
Abstract: Piper, the pepper plants or pepper vines are an economically and ecologically important genus in the family Piperaceae. It contains about 1,000-2,000 species of shrubs, herbs, and lianas, many of which are keystone species in their native habitat. Piper species have a pan tropical distribution, and are most commonly found in the understory of lowland tropical rainforests, but can also occur in clearings and in higher elevation life zones such as cloud forests. Most Piper species are either herbaceous or vines; some grow as shrubs or almost as small trees. Many species of piper have been used for treating different diseases in many traditions. E.g P. cubeba has been used in folk medicine, herbalism as well as in the early 20th century, as a cigarette flavoring. P. darienense is used medically by the Kuna people of the Panama-Colombia border region, and elsewhere it is used to intoxicate fish which then can be easily caught. Black Pepper (P. nigrum) essential oil is sometimes used in herbalism, and Long Pepper (P. longum) is similarly employed in Ayurveda, where it was an ingredient of Triphala Guggulu and (together with Black Pepper) of Trikatu pills, used for rasayana (rejuvenating and detoxifying) purposes.
Citations
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Journal ArticleDOI
TL;DR: The functional properties of Piper plants/extracts/active components the antiproliferative, anti-inflammatory, and neuropharmacological activities of the extracts and extract-derived bioactive constituents are thought to be key effects for the protection against chronic conditions.
Abstract: Piper species are aromatic plants used as spices in the kitchen, but their secondary metabolites have also shown biological effects on human health. These plants are rich in essential oils, which can be found in their fruits, seeds, leaves, branches, roots and stems. Some Piper species have simple chemical profiles, while others, such as Piper nigrum, Piper betle, and Piper auritum, contain very diverse suites of secondary metabolites. In traditional medicine, Piper species have been used worldwide to treat several diseases such as urological problems, skin, liver and stomach ailments, for wound healing, and as antipyretic and anti-inflammatory agents. In addition, Piper species could be used as natural antioxidants and antimicrobial agents in food preservation. The phytochemicals and essential oils of Piper species have shown strong antioxidant activity, in comparison with synthetic antioxidants, and demonstrated antibacterial and antifungal activities against human pathogens. Moreover, Piper species possess therapeutic and preventive potential against several chronic disorders. Among the functional properties of Piper plants/extracts/active components the antiproliferative, anti-inflammatory, and neuropharmacological activities of the extracts and extract-derived bioactive constituents are thought to be key effects for the protection against chronic conditions, based on preclinical in vitro and in vivo studies, besides clinical studies. Habitats and cultivation of Piper species are also covered in this review. In this current work, available literature of chemical constituents of the essential oils Piper plants, their use in traditional medicine, their applications as a food preservative, their antiparasitic activities and other important biological activities are reviewed.

241 citations


Cites background from "Introduction, phytochemistry, tradi..."

  • ...Piper obliquum leaves are utilized in the Central and South America, especially Guyana and Ecuador, as analgesic or antiarthritic by topic application on the affected body part [36,115]....

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  • ...hispidum has been traditionally used to treat wounds and symptoms of cutaneous leishmaniasis, skin ailments, and stomach aches [115,154,174,175]....

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  • ...Moreover, the fruits have been used in traditional remedies against intestinal distress with the ripe fruits also applied as an alternative to tonic [115]....

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  • ...Piper laetispicum, popularly known in the southern part of China folk medicine, is used for reducing stasis and promoting blood circulation, which are claimed to be useful in antiplatelet therapies and in the treatment of thrombotic diseases [121], and as an analgesic [115]....

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  • ...capense is traditionally used in Comoro Islands for diarrhea and cough [115,125]....

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Journal ArticleDOI
TL;DR: New discoveries related to the phytochemistry and biological activities of bioactive compounds from Piper species are reviewed for further clinical applications, which could pave the way for the proper therapeutic use ofBioactive compounds and extracts from this plant species.

118 citations

Journal ArticleDOI
TL;DR: The Venda area is rich in plant diversity and local indigenous knowledge of medicinal plants can play an important role as a model for low cost primary health care, according to the main factors threatening the conservation status of these plants.

67 citations


Cites background from "Introduction, phytochemistry, tradi..."

  • ...…21 S 18 b Grind dry bark into fine powder and boil Oral, 1 cup taken 3x per day (Steenkamp et al., 2007) Sore throat (Mabogo, 1990) Diarrhoea, cough (Chahal et al., 2011), Ulcers, fever (Obi et al., 2002) Pterocarpus rotundifolius Druce, Fabaceae Muataha Rn 29 T 9 st b Grind bark into fine powder…...

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20 May 2020
TL;DR: Universidad Nacional de Colombia -Sede Bogota, Pontificia Universidad Javeriana, MinCiencias as discussed by the authors, MinCientías
Abstract: Universidad Nacional de Colombia - Sede Bogota, Pontificia Universidad Javeriana, MinCiencias

34 citations

Journal ArticleDOI
TL;DR: Essential oils from stems, flowers, and leaves of Piper marginatum Jacq.
Abstract: Tetranychus urticae Koch (Acari: Tetranychidae) is an economically important pest of agricultural and ornamental crops worldwide. It has been shown that many of natural plant-based pesticides have fewer side effects compared with synthetic chemicals. The essential oils of plants have been broadly studied for pest-control, including toxic and repellent effects, antifeedant, ovicidal, and other properties. Essential oils from stems, flowers, and leaves of Piper marginatum Jacq. were evaluated in the laboratory regarding their acaricidal potential against the two-spotted spider mite (T. urticae) and the results were compared with eugenol as a positive control. The oils were also evaluated with regard to the susceptibility of the natural enemy of T. urticae (Neoseiulus californicus McGregor). Based on LC50 estimates, oils from stems and flowers exhibited the same toxicity and differed significantly from the leaf oil with LC50 0.37, 0.56, and 3.77 μL L -1 , respectively. None of the oils tested exhibited toxicity greater than or equal to that of the positive control. The oil mortality rate was significantly lower for N. californicus (50% to 70%) than for T. urticae (> 95%). The P. marginatum oils also deterred oviposition. Among the chemical constituents tested, sesquiterpenes were more toxic with an LC50 of 2.89 μL L -1 than phenylpropanoids Z-asarone and E-asarone with LC50 6.64 and 8.51 μL L -1 , respectively. The acaricidal

33 citations

References
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Journal ArticleDOI
TL;DR: Chromatography permits not only the detection of fungitoxic substances per se, but also makes the study of the conversion reactions and of decomposition of such compounds possible.

559 citations

Journal ArticleDOI
TL;DR: Administration of alcoholic extract of Piper longum as well as piperine could inhibit the solid tumor development in mice induced with DLA cells and increase the life span of mice bearing Ehrlich ascites carcinoma tumor to 37.3 and 58.8%, respectively.

442 citations

Journal ArticleDOI
TL;DR: In this paper, three local varieties of Piper betle leaves were evaluated by several in vitro systems, e.g., DPPH radical scavenging activity, superoxide radical scavengence activity in a riboflavin/light/NBT system, hydroxyl radical scavenges activity and inhibition of lipid peroxidation induced by FeSO 4 in egg yolk.

306 citations

Journal ArticleDOI
TL;DR: The results support other studies on Asian and African Piper species, which suggest that lignans and isobutyl amides are the active defence compounds in this family.
Abstract: Insecticidal and growth-reducing properties of extracts of 14 species of American neotropical Piperaceae were investigated by inclusion in diets of a polyphagous lepidopteran, the European corn borer,Ostrinia nubilalis. Nutritional indices suggested most extracts acted by postdigestive toxicity.Piper aduncum, P. tuberculatum, andP. decurrens were among the most active species and were subjected to bioassay-guided isolation of the active components. Dillapiol was isolated from the active fraction ofP. aduncum, piperlonguminine was isolated fromP. tuberculatum, and a novel neolignan fromP. decurrens. The results support other studies on Asian and AfricanPiper species, which suggest that lignans and isobutyl amides are the active defence compounds in this family.

178 citations