Investigation of Anatomical Thalamo-Cortical Connectivity and fMRI Activation in Schizophrenia

doi:10.1038/NPP.2011.215

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Investigation of Anatomical Thalamo-Cortical Connectivity and fMRI Activation in Schizophrenia

Journal Article•DOI•

Investigation of Anatomical Thalamo-Cortical Connectivity and fMRI Activation in Schizophrenia

Stefano Marenco, Jason L. Stein, Antonina A. Savostyanova, Fabio Sambataro¹, Hao Yang Tan, Aaron L. Goldman, Beth A. Verchinski, Alan S. Barnett, Dwight Dickinson, Jose A. Apud, Joseph H. Callicott, Andreas Meyer-Lindenberg, Daniel R. Weinberger - Show less +9 more•Institutions (1)

Istituto Italiano di Tecnologia¹

01 Jan 2012-Neuropsychopharmacology (Nature Publishing Group)-Vol. 37, Iss: 2, pp 499-507

TL;DR: Thalamocortical connectivity to the LPFC is altered in schizophrenia with functional consequences on working memory processing in LPFC, and the correlation with BOLD activation was accentuated in patients as compared with controls in the ventral LPFC.

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About: This article is published in Neuropsychopharmacology.The article was published on 2012-01-01 and is currently open access. It has received 144 citations till now. The article focuses on the topics: Prefrontal cortex & Working memory.

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Journal Article•DOI•

Dynamic functional connectivity analysis reveals transient states of dysconnectivity in schizophrenia

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Eswar Damaraju¹, Elena A. Allen¹, Elena A. Allen², Aysenil Belger³, Judith M. Ford⁴, Judith M. Ford⁵, Sarah McEwen⁶, Daniel H. Mathalon⁴, Daniel H. Mathalon⁵, Bryon A. Mueller⁷, Godfrey D. Pearlson⁸, Steven G. Potkin⁹, Adrian Preda⁹, Jessica A. Turner¹⁰, Jatin G. Vaidya¹¹, T.G.M. van Erp⁹, Vince D. Calhoun¹, Vince D. Calhoun¹² - Show less +14 more•Institutions (12)

The Mind Research Network¹, University of Bergen², University of North Carolina at Chapel Hill³, University of California, San Francisco⁴, Veterans Health Administration⁵, University of California, Los Angeles⁶, University of Minnesota⁷, Yale University⁸, University of California, Irvine⁹, Georgia State University¹⁰, University of Iowa¹¹, University of New Mexico¹²

01 Jan 2014-NeuroImage: Clinical

TL;DR: The results support and expand current knowledge regarding dysconnectivity in schizophrenia, and strongly advocate the use of dynamic analyses to better account for and understand functional connectivity differences.

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906 citations

Journal Article•DOI•

Thalamocortical dysconnectivity in schizophrenia.

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Neil D. Woodward¹, Haleh Karbasforoushan, Stephan Heckers•Institutions (1)

Vanderbilt University¹

01 Oct 2012-American Journal of Psychiatry

TL;DR: The etiology of schizophrenia may disrupt the development of prefrontal-thalamic connectivity and refinement of somatomotor connectivity with the thalamus that occurs during brain maturation, establishing differential abnormalities of thalamocortical networks in schizophrenia.

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Abstract: ObjectiveThe thalamus and cerebral cortex are connected via topographically organized, reciprocal connections. Previous studies have revealed thalamic abnormalities in schizophrenia; however, it is not known whether thalamocortical networks are differentially affected in the disorder. To explore this possibility, the authors examined functional connectivity in intrinsic low-frequency blood-oxygen-level-dependent (BOLD) signal fluctuations between major divisions of the cortex and thalamus using resting-state functional MRI (fMRI).MethodSeventy-seven healthy subjects and 62 patients with schizophrenia underwent resting-state fMRI. To identify functional subdivisions of the thalamus, the authors parceled the cortex into six regions of interest: the prefrontal cortex, motor cortex/supplementary motor area, somatosensory cortex, temporal lobe, posterior parietal cortex, and occipital lobe. Mean BOLD time series were extracted for each region of interest and entered into a seed-based functional connectivity an...

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411 citations

Cites background from "Investigation of Anatomical Thalamo..."

...functional consequences of these changes remain to be characterized; however, reduced structural connectivity between the prefrontal cortex and thalamus has been linked to working memory impairment and prefrontal brain activity in schizophrenia (26)....
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...Results from a recent diffusion tensor imaging investigation demonstrating reduced connectivity between the thalamus and lateral prefrontal cortex and increased connectivity between the somatosensory cortex and thalamus in schizophrenia provide a potential anatomical basis for our findings (26)....
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Journal Article•DOI•

Characterizing Thalamo-Cortical Disturbances in Schizophrenia and Bipolar Illness

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Alan Anticevic¹, Michael W. Cole², Grega Repovs³, John D. Murray¹, Margaret S. Brumbaugh⁴, Anderson M. Winkler¹, Aleksandar Savić¹, John H. Krystal⁵, John H. Krystal¹, Godfrey D. Pearlson¹, David C. Glahn¹ - Show less +7 more•Institutions (5)

Yale University¹, Washington University in St. Louis², University of Ljubljana³, Hartford Hospital⁴, National Institutes of Health⁵

01 Dec 2014-Cerebral Cortex

TL;DR: Classification and cross-diagnostic results suggest that thalamic dysconnectivity may be a neural marker for disturbances across diagnoses, and basic understanding of large-scale thalamo-cortical systems is informed.

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Abstract: Schizophrenia is a devastating neuropsychiatric syndrome associated with distributed brain dysconnectivity that may involve large-scale thalamo-cortical systems. Incomplete characterization of thalamic connectivity in schizophrenia limits our understanding of its relationship to symptoms and to diagnoses with shared clinical presentation, such as bipolar illness, which may exist on a spectrum. Using resting-state functional magnetic resonance imaging, we characterized thalamic connectivity in 90 schizophrenia patients versus 90 matched controls via: (1) Subject-specific anatomically defined thalamic seeds; (2) anatomical and data-driven clustering to assay within-thalamus dysconnectivity; and (3) machine learning to classify diagnostic membership via thalamic connectivity for schizophrenia and for 47 bipolar patients and 47 matched controls. Schizophrenia analyses revealed functionally related disturbances: Thalamic over-connectivity with bilateral sensory–motor cortices, which predicted symptoms, but thalamic under-connectivity with prefrontal–striatal–cerebellar regions relative to controls, possibly reflective of sensory gating and top-down control disturbances. Clustering revealed that this dysconnectivity was prominent for thalamic nuclei densely connected with the prefrontal cortex. Classification and cross-diagnostic results suggest that thalamic dysconnectivity may be a neural marker for disturbances across diagnoses. Present findings, using one of the largest schizophrenia and bipolar neuroimaging samples to date, inform basic understanding of large-scale thalamo-cortical systems and provide vital clues about the complex nature of its disturbances in severe mental illness.

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410 citations

Cites result from "Investigation of Anatomical Thalamo..."

...Identified thalamo-cortical disruptions in schizophrenia seem to follow a functional anatomical dissociation between frontal– control and sensory cortices, in line with recent anatomical evidence (Marenco et al. 2012)....
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...control and sensory cortices, in line with recent anatomical evidence (Marenco et al. 2012)....
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Journal Article•DOI•

Inhibition of mediodorsal thalamus disrupts thalamofrontal connectivity and cognition.

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Sébastien Parnaudeau, Pia-Kelsey O’Neill, Scott S. Bolkan, Ryan D. Ward, Atheir I. Abbas, Bryan L. Roth¹, Peter D. Balsam, Joshua A. Gordon, Christoph Kellendonk² - Show less +5 more•Institutions (2)

University of North Carolina at Chapel Hill¹, Columbia University²

20 Mar 2013-Neuron

TL;DR: It is found that a subtle decrease in MD activity is sufficient to trigger selective impairments in prefrontal-dependent cognitive tasks and could contribute to the cognitive symptoms observed in schizophrenia.

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330 citations

Cites background from "Investigation of Anatomical Thalamo..."

...Structural abnormalities in this circuit have also been reported (Byne et al., 2009; Marenco et al., 2012)....
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Journal Article•DOI•

Review of functional and anatomical brain connectivity findings in schizophrenia.

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Jennifer Fitzsimmons¹, Marek Kubicki, Martha E. Shenton•Institutions (1)

Brigham and Women's Hospital¹

01 Mar 2013-Current Opinion in Psychiatry

TL;DR: Advances in DTI and in combining DTI with fMRI provide new insight into anatomical and functional connections in the brain, and for studying dysconnectivity in schizophrenia.

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Abstract: Purpose of reviewWe review diffusion tensor imaging (DTI) studies that investigate white matter abnormalities in patients with chronic schizophrenia, first episode schizophrenia, and those who are at genetic risk for developing schizophrenia. Additionally, we include studies that combine DTI and fun

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278 citations

Cites background from "Investigation of Anatomical Thalamo..."

...[29] examined measures of anatomical connectivity between the thalamus and lateral prefrontal cortex and suggested that thalamo-cortical connectivity to the lateral prefrontal cortex is altered in patients with CHSZ, which may have functional consequences for working memory....
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References

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Journal Article•DOI•

An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest.

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Rahul S. Desikan¹, Florent Ségonne², Bruce Fischl², Bruce Fischl³, Brian T. Quinn³, Bradford C. Dickerson³, Deborah Blacker³, Randy L. Buckner⁴, Randy L. Buckner³, Anders M. Dale⁵, R. Paul Maguire⁶, Bradley T. Hyman³, Marilyn S. Albert⁷, Ronald J. Killiany¹ - Show less +10 more•Institutions (7)

Boston University¹, Massachusetts Institute of Technology², Harvard University³, Howard Hughes Medical Institute⁴, University of California, San Diego⁵, Pfizer⁶, Johns Hopkins University School of Medicine⁷

01 Jul 2006-NeuroImage

TL;DR: An automated labeling system for subdividing the human cerebral cortex into standard gyral-based neuroanatomical regions is both anatomically valid and reliable and may be useful for both morphometric and functional studies of the cerebral cortex.

...read moreread less

9,940 citations

Four Factor Index of Social Status

[...]

Roi Paschou

01 Jan 1975

7,114 citations

Journal Article•DOI•

A global optimisation method for robust affine registration of brain images

[...]

Mark Jenkinson¹, Stephen M. Smith¹•Institutions (1)

John Radcliffe Hospital¹

01 Jun 2001-Medical Image Analysis

TL;DR: It is demonstrated that the use of local optimisation methods together with the standard multi-resolution approach is not sufficient to reliably find the global minimum, so a global optimisation method is proposed that is specifically tailored to this form of registration.

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6,413 citations

"Investigation of Anatomical Thalamo..." refers methods in this paper

...Images were corrected for distortion caused by eddy currents and head motion using an affine registration to the first nondiffusion-weighted volume (Jenkinson and Smith, 2001)....
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...Affine registration (Jenkinson and Smith, 2001) using a normalized mutual information cost function with 12 degrees of freedom was used for each participant to derive transformation matrices from the non-diffusion-weighted image of the DTI series to the structural T1-weighted image....
[...]

Journal Article•DOI•

Probabilistic diffusion tractography with multiple fibre orientations: What can we gain?

[...]

Behrens Tej.¹, H J Berg¹, Saad Jbabdi¹, Rushworth Mfs.¹, Mark W. Woolrich¹ - Show less +1 more•Institutions (1)

University of Oxford¹

01 Jan 2007-NeuroImage

TL;DR: It is shown that multi-fibre tractography offers significant advantages in sensitivity when tracking non-dominant fibre populations, but does not dramatically change tractography results for the dominant pathways.

...read moreread less

3,315 citations

"Investigation of Anatomical Thalamo..." refers methods in this paper

...The brain was extracted and the diffusion parameters were estimated (Behrens et al, 2007), giving a probability distribution function of two fibers in each voxel of the brain....
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Journal Article•DOI•

Characterization and propagation of uncertainty in diffusion-weighted MR imaging.

[...]

Timothy E.J. Behrens¹, Mark W. Woolrich¹, Mi Jenkinson¹, Heidi Johansen-Berg¹, Rita G. Nunes¹, Stuart Clare¹, Paul M. Matthews¹, J M Brady¹, Stephen M. Smith¹ - Show less +5 more•Institutions (1)

University of Oxford¹

01 Nov 2003-Magnetic Resonance in Medicine

TL;DR: A fully probabilistic framework is presented for estimating local probability density functions on parameters of interest in a model of diffusion, allowing for the quantification of belief in tractography results and the estimation of the cortical connectivity of the human thalamus.

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Abstract: A fully probabilistic framework is presented for estimating local probability density functions on parameters of interest in a model of diffusion. This technique is applied to the estimation of parameters in the diffusion tensor model, and also to a simple partial volume model of diffusion. In both cases the parameters of interest include parameters defining local fiber direction. A technique is then presented for using these density functions to estimate global connectivity (i.e., the probability of the existence of a connection through the data field, between any two distant points), allowing for the quantification of belief in tractography results. This technique is then applied to the estimation of the cortical connectivity of the human thalamus. The resulting connectivity distributions correspond well with predictions from invasive tracer methods in nonhuman primate.

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2,970 citations

"Investigation of Anatomical Thalamo..." refers methods in this paper

...This technique has allowed researchers to segment the thalamus in functionally relevant connectivity-defined regions (CDRs) based on their preferential connectivity to particular cortical areas (Behrens et al, 2003a, b; Johansen-Berg et al, 2005; Klein et al, 2010)....
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