Figure 5. Tube formation and endothelial sprouting are inhibited by spongistatin 1. A) Representative images of tube formation. S.CORE tube formation analysis determines cellular structures as tubes (dark gray) and nodes (light gray). B) Tube formation of endothelial cells on Matrigel was reduced to half by 1.0 nM spongistatin 1 (SP1), 5.0 nM vinblastine (vinb), 10.0 nM CA4P, and 50.0 nM paclitaxel (pacl). *P 0.05; 1-way ANOVA. C) Representative pictures of aortic ring assay showing vascular sprouting of the 3 treatment groups (control and 0.5 and 1.0 nM spongistatin 1).
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