Figure 6. Spongistatin 1 inhibits neovascularization of mouse corneas. A) Corneal neovascularization was examined and photographed on day 6 after implantation of pellets containing bFGF ( 20 view of mouse eye; dots encircle area of implanted pellet). Corneal neovascularization in spongistatin 1-treated animals was markedly reduced compared to vehicletreated control animals (control). B, C) Angiogenic responses were measured as clock hours (B) and vessel length of neovascularization (C). *P 0.001; Student’s t test.
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