Investigation of the toxicological and inhibitory effects of some benzimidazole agents on acetylcholinesterase and butyrylcholinesterase enzymes.
04 Mar 2021-Archives of Physiology and Biochemistry (Arch Physiol Biochem)-Vol. 127, Iss: 2, pp 97-101
TL;DR: Study findings have shown that benzimidazoles inhibit both AChE and BChE enzymes at the nanomolar level, and the compound that best was inhibited the A cholinesterase ricobendazole, and it was that the best inhibited the BchE enzyme thiabendazoles.
Abstract: Benzimidazole, an anthelmintic used in the manufacture of human and veterinary drugs, is an important heterocyclic compound. In this work, I investigated the effect of drugs such as ricobendazole, ...
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TL;DR: In this article, two different Schiff base Fe(II) and Co-II metal complex compounds were synthesized with Schiff base obtained through the condensation of 1-(4-aminophenyl)ethanone with 2-hydroxy-3-methoxybenzaldehyde.
Abstract: Considering the importance of metal complexes in the development of medical science, two different Schiff base Fe(II) and Co(II) metal complex compounds were synthesized with Schiff base obtained through the condensation of 1-(4-aminophenyl)ethanone with 2-hydroxy-3-methoxybenzaldehyde. The reactions of the ligand with Co(II) and Fe(II) metal ions enabled six coordination compounds with octahedral geometries. The novel metal complexes were characterized by IR, elemental analyses, magnetic susceptibility, mass spectra, UV–Vis, thermogravimetry–differential thermal analysis (TGA–DTA) and X-ray diffraction analysis. The antioxidant properties of the new compounds were investigated using different in vitro assays. Moreover, enzyme inhibition of derivatives complexes against carbonic anhydrase I and II isoenzymes (CA I and II) and acetylcholinesterase (AChE) was evaluated. The best inhibitor complex for CA I and II isoenzymes was the Fe(II) complex with Ki values of 52.83 ± 11.52 and 63.34 ± 8.88, respectively.
44 citations
TL;DR: The inhibition type of the 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives at the receptors was determined and the data obtained in this work was evaluated.
43 citations
TL;DR: Inhibitory effect of the complexes on some metabolic enzyme demonstrated that the enzymes inhibited by ligand and it’s complex molecules at the micromolar level are demonstrated.
Abstract: Inhibitory effect of the complexes on some metabolic enzyme results demonstrated that the enzymes inhibited by ligand and it’s complex molecules at the micromolar level. The best inhibition effect ...
26 citations
TL;DR: The features obtained from the 2D-QSAR modeling suggest that the number of aromatic ethers, unsaturation content relative to the molecular size and molecular shape may be more specific for the inhibition of the AChE enzyme in comparison to the BuChE enzymes.
23 citations
TL;DR: In this article, the synthesis of new cobalt and zinc phthalocyanine compounds with ((ethylenediamine-N,N, N’,N’-triacetic acid-N-2-ethyl)oxy) (ETAEO) substituted groups was reported.
9 citations
References
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TL;DR: A photometric method for determining acetylcholinesterase activity of tissue extracts, homogenates, cell suspensions, etc., has been described and Kinetic constants determined by this system for erythrocyte eholinesterases are presented.
23,015 citations
TL;DR: A highly stable pillared and double-walled zinc(II) metal-organic framework with regular nanochannels displays single-crystal to single-Crystal transformation upon desolvation and a large quantity of iodine uptake, controlled release, and electrical conductivity elevation due to synergy between the iodine guests and the host framework.
Abstract: A highly stable pillared and double-walled zinc(II) metal-organic framework with regular nanochannels displays single-crystal to single-crystal transformation upon desolvation and a large quantity of iodine uptake, controlled release, and electrical conductivity elevation due to synergy between the iodine guests and the host framework.
592 citations
TL;DR: Ernest Lacey examines this example of selectivity of drug action to the ubiquitous target of these drugs, the structural protein, tubulin, and investigates why benzimidazoles can selectively kill helminths and yet exhibit little or no mammalian toxicity.
513 citations
"Investigation of the toxicological ..." refers background in this paper
...GST enzymes are a multifunctional enzyme group that functions in cellular detoxification, and it catalyzes nonpolar compounds that contain electrophilic conjugates containing carbon, nitrogen, and sulfur atoms (Lacey 1990)....
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TL;DR: Green tea polyphenols are now being considered as therapeutic agents in well controlled epidemiological studies, aimed to alter brain aging processes and to serve as possible neuroprotective agents in progressive neurodegenerative disorders such as Parkinson's and Alzheimer's diseases.
Abstract: Tea consumption is varying its status from a mere ancient beverage and a lifestyle habit, to a nutrient endowed with possible prospective neurobiological-pharmacological actions beneficial to human health. Accumulating evidence suggest that oxidative stress resulting in reactive oxygen species generation and inflammation play a pivotal role in neurodegenerative diseases, supporting the implementation of radical scavengers, transition metal (e.g., iron and copper) chelators, and nonvitamin natural antioxidant polyphenols in the clinic. These observations are in line with the current view that polyphenolic dietary supplementation may have an impact on cognitive deficits in individuals of advanced age. As a consequence, green tea polyphenols are now being considered as therapeutic agents in well controlled epidemiological studies, aimed to alter brain aging processes and to serve as possible neuroprotective agents in progressive neurodegenerative disorders such as Parkinson's and Alzheimer's diseases. In particular, literature on the putative novel neuroprotective mechanism of the major green tea polyphenol, (-)-epigallocatechin-3-gallate, are examined and discussed in this review.
469 citations
"Investigation of the toxicological ..." refers background in this paper
...AChE, neurotransmitter acetylcholine (ACh) in cholinergic synapses and neuromuscular synapses which rapidly hydrolyze into choline and acetate playing an important role in the transmission of cholinergic nerve and is one of the most effective enzymes in the nervous system (Weinreb et al. 2004)....
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TL;DR: The 3D metal-organic framework (MOF) (3)(infinity) is found to be a reversibly dehydratable-hydratable water-stable MOF material with a large loading spread as a candidate for solid adsorbents in heat transformation cycles for refrigeration, heat pumping, and heat storage.
Abstract: The 3D metal−organic framework (MOF) 3∞{[Ni3(μ3-btc)2(μ4-btre)2(μ-H2O)2]·∼22H2O} is found to be a reversibly dehydratable−hydratable water-stable MOF material with a large loading spread of 210 g/kg as a candidate for solid adsorbents in heat transformation cycles for refrigeration, heat pumping, and heat storage.
407 citations
"Investigation of the toxicological ..." refers background in this paper
...Tiabendazole (TBZ) has aroused considerable interest in biology and medicine due to its antiproliferative activities (Zeng et al. 2010, Kumar et al. 2006, Lu, et al. 2006, Henninger et al. 2009)....
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