Open AccessJournal Article
Investigations on the occlusive properties of solid lipid nanoparticles (SLN).
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TLDR
Solid lipid nanoparticles (SLN) represent a novel carrier system for controlled release of topical cosmetic and pharmaceutical compounds and in addition to their controlled release characteristics, it has been found that SLN have an occlusive effect.Abstract:
Skin hydration can be influenced to a great extent by occlusive compounds. Conventional highly occlusive compounds tend to have an unacceptable appearance. Therefore, the development of innovative occlusive topicals is an essential issue regarding the formulation of cosmetic and pharmaceutical preparations. Solid lipid nanoparticles (SLN) represent a novel carrier system for controlled release of topical cosmetic and pharmaceutical compounds. In addition to their controlled release characteristics, it has been found that SLN have an occlusive effect. The extent of the occlusive effect depends on various factors such as particle size, applied sample volume, lipid concentration, and crystallinity of the lipid matrix. These factors have been investigated in detail by an in vitro test, and the obtained data give insight into their importance.read more
Citations
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Journal ArticleDOI
Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations.
TL;DR: As a novel type of lipid nanoparticles with solid matrix, the nanostructured lipid carriers (NLC) are presented and improvements discussed, for example, increase in loading capacity, physical and chemical long-term stability, triggered release and potentially supersaturated topical formulations.
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Lipid nanoparticles (SLN, NLC) in cosmetic and pharmaceutical dermal products.
TL;DR: An overview of the cosmetic products currently on the market is given and the improvement of the benefit/risk ratio of the topical therapy is shown and the lipid nanoparticles are a "nanosafe" carrier.
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Development of Nanoparticles for Antimicrobial Drug Delivery
TL;DR: The current progress and challenges in synthesizing nanoparticle platforms for delivering various antimicrobial drugs are reviewed and the need to unite the shared interest between nanoengineers and microbiologists in developing nanotechnology for the treatment of microbial diseases is called attention.
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Solid lipid nanoparticles: a modern formulation approach in drug delivery system.
TL;DR: A broad treatment of solid lipid nanoparticles is presented discussing their advantages, limitations and their possible remedies, as well as different types of nanocarriers which were based on solid lipid like solid cholesterol nanoparticles, nanostructured lipid carriers, lipid drug conjugates are discussed.
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Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery.
TL;DR: The obtained results demonstrate the use of these lipid nanoparticles as modified release formulations for lipophilic drugs over a period of 10 h, and the entrapment efficiency was higher than 50%.
References
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Journal ArticleDOI
Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art.
TL;DR: Relevant issues for the introduction of SLN to the pharmaceutical market, such as status of excipients, toxicity/tolerability aspects and sterilization and long-term stability including industrial large scale production are discussed.
Journal ArticleDOI
Vitamin A loaded solid lipid nanoparticles for topical use: occlusive properties and drug targeting to the upper skin.
TL;DR: Enhanced retinol palmitate uptake should derive from specific SLN effects and is not due to non-specific occlusive properties, as Transepidermal water loss (TEWL) and the influence of drug free SLN on retinyl palmitates uptake exclude pronounced Occlusive effects.
Journal ArticleDOI
Vitamin A-loaded solid lipid nanoparticles for topical use: drug release properties.
TL;DR: A good correlation between polymorphic transitions and increased drug release was observed in this study and was often related to the metastable beta' polymorph.
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Solid lipid nanoparticles (SLN) : an alternative colloidal carrier system for controlled drug delivery
Rainer H. Müller,W. Mehnert,J.S. Lucks,C. Schwarz,A. zur Mühlen,H. Meyhers,C. Freitas,D. Rühl +7 more
TL;DR: Solid lipid nanoparticles of optimized composition proved to be physically stable during sterilization (autoclaving) and on long-term as aqueous dispersion as well as in vitro drug release over 5 weeks (prednisolone).
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Crystallization tendency and polymorphic transitions in triglyceride nanoparticles
TL;DR: The ability of tristearin, tripalmitin, trimyristin and trilaurin to form solid lipid nanoparticles after melt-homogenization is investigated by DSC and X-ray diffraction.
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