Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100 Gy/s
Citations
403 citations
Cites background or methods or result from "Irradiation in a flash: Unique spar..."
...Using CD34 as a surrogate marker of the epidermal stem cells (23), our results suggest that FLASH-irradiated skin area retain the expression of CD34 supporting the idea that FLASH-RT has minimal impact on stem cell consistently with what was already reported for neural (2) and intestinal stem cells (7)....
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...Interestingly, the group of B. Loo at Stanford University (Palo Alto, CA) recently published a procedure on how to modify a clinical linac into an irradiator capable of delivering FLASH-RT, with dose rates exceeding 200 Gy/second (6) and produced preliminary data showing gut protection in mice (7)....
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...In vivo dosimetry was performed withfilm (Gafchromic EBT3) and alaninepellets (2, 3) positioned on the skin surface in the center of the beams....
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...With the objective of fostering innovation in radiotherapy, we have been the first to propose a completely novel modality of irradiation, named FLASH radiotherapy (FLASH-RT), that markedly increases the differential effect between tumors and normal tissues and is able to destroy tumors, while better protecting normal tissues and preventing side effects in experimental models (1, 2)....
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...This enhanced tolerance of normal tissues appears at irradiation dose rates above 30–40 Gy/second, whereas on all the tumor models tested so far, FLASH-RT has been shown to be as effective for tumor control as Conv-RT (Montay-Gruel and Vozenin, in preparation; ref....
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340 citations
285 citations
279 citations
Cites background or methods or result from "Irradiation in a flash: Unique spar..."
...Whole brain irradiation of mice (14) Novel object recognition test >1...
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...using a wide range of dose rates has helped to elucidate the extent to which dose rate modulates the FLASH effect (14)....
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...The FLASH effect has been predominantly observed following FLASH-RT using dedicated electron linear accelerators as the source of radiation (10, 14, 15, 18, 37)....
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...In addition to thoracic irradiation, it has been shown in several studies that whole brain irradiation using FLASH-RT confers neuroprotection compared to CONV-RT (13, 14, 24, 25)....
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...Furthermore, there was no statistical difference in novel object recognition between mice irradiated at dose rates exceeding 100 Gy/s and non-irradiated mice (14)....
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277 citations
References
1,635 citations
"Irradiation in a flash: Unique spar..." refers methods in this paper
...Dose rate effect on neuroprotection was evaluated by ‘‘Novel Object Recognition test” [18], performed on the mice two months post-irradiation, as described by Acharya et al....
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...These cognitive impairments can be evaluated using the ‘‘Novel Object Recognition test” [18] on WBI murine models [19]....
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1,469 citations
1,257 citations
"Irradiation in a flash: Unique spar..." refers background in this paper
...Both neuroinflammation [27] and synaptic changes [28] are known to interfere with cognitive functions after WBI and could be differentially induced after Flash WBI....
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696 citations
"Irradiation in a flash: Unique spar..." refers background or result in this paper
...Our previous results show that Flash-RT demonstrates an antitumor effect similar to conventional radiotherapy [1] in various tumor types, including glioblastoma (preliminary in vitro and in vivo data)....
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...When compared to radiotherapy delivered at conventional dose rates (1–4 Gy/min), this so called ‘‘Flash” radiotherapy (>40 Gy/s; Flash-RT) was shown to enhance the differential effect between normal tissue and tumor in lung models [1,2] and consequently allowed for dose escalation....
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668 citations
"Irradiation in a flash: Unique spar..." refers background in this paper
...Cognitive impairments are the most described functional defects observed in mice and humans following WBI [4,16]....
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