Journal ArticleDOI
Irreversible Electroporation in Locally Advanced Pancreatic Cancer: Potential Improved Overall Survival
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TLDR
IRE ablation of locally advanced pancreatic tumors remains safe and in the appropriate patient who has undergone standard induction therapy for a minimum of 4 months can achieve greater local palliation and potential improved overall survival compared with standard chemoradiation–chemotherapy treatments.Abstract:
Background
Locally advanced unresectable pancreatic adenocarcinoma (LAC) is characterized by poor survival despite chemotherapy and conventional radiation therapy. We have recently reported on the safety of using irreversible electroporation (IRE) for the management of LAC. The purpose of this study was to evaluate the overall survival in patients with LAC treated with IRE.read more
Citations
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Journal ArticleDOI
Irreversible electroporation for nonthermal tumor ablation in the clinical setting: a systematic review of safety and efficacy.
Hester J. Scheffer,Karin Nielsen,Marcus C. de Jong,Aukje A. J. M. van Tilborg,J.M. Vieveen,Arthur R A Bouwman,Sybren L. Meijer,Cornelis van Kuijk,Petrousjka van den Tol,Martijn R. Meijerink +9 more
TL;DR: Overall, the future of IRE for difficult-to-reach tumors appears promising, and in cases where other techniques are unsuitable, IRE is a promising modality for the ablation of tumors near bile ducts and blood vessels.
Journal ArticleDOI
Treatment of 200 locally advanced (stage III) pancreatic adenocarcinoma patients with irreversible electroporation: safety and efficacy.
Robert C.G. Martin,David Kwon,Sricharan Chalikonda,Marty Sellers,Eric Kotz,Charles R. Scoggins,Kelly M. McMasters,Kevin Watkins +7 more
TL;DR: For patients with LAPC (stage III), the addition of IRE to conventional chemotherapy and radiation therapy results in substantially prolonged survival compared with historical controls, suggesting that ablative control of the primary tumor may prolong survival.
Journal ArticleDOI
A Review of Basic to Clinical Studies of Irreversible Electroporation Therapy
TL;DR: This study reviews the in vitro, translational, and clinical studies of IRE cancer therapy based on major experimental studies particularly within the past decade and provides organized data and facts to assist further research, optimization, and patients' needs.
Journal ArticleDOI
Systematic review of innovative ablative therapies for the treatment of locally advanced pancreatic cancer.
Steffi J.E. Rombouts,Jantien A. Vogel,H.C. van Santvoort,K.P. van Lienden,R. van Hillegersberg,O.R.C. Busch,Marc G. Besselink,I. Q. Molenaar +7 more
TL;DR: A systematic review of the clinical outcomes of several innovative local ablative therapies for locally advanced pancreatic cancer aims to provide an overview of their clinical outcomes.
Journal ArticleDOI
Safety and feasibility of Irreversible Electroporation (IRE) in patients with locally advanced pancreatic cancer: results of a prospective study.
Salvatore Paiella,Giovanni Butturini,Isabella Frigerio,Roberto Salvia,Giulia Armatura,Matilde Bacchion,Martina Fontana,Mirko D'Onofrio,Enrico Martone,Claudio Bassi +9 more
TL;DR: Irreversible Electroporation is a safe procedure in patients with LAPC and may represent a new technological option in the treatment and multimodality management of this disease.
References
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Journal ArticleDOI
Global cancer statistics
TL;DR: A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination, and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake.
PatentDOI
Tissue ablation with irreversible electroporation
Rafael V. Davalos,Boris Rubinsky +1 more
TL;DR: In this paper, a new method for the ablation of undesirable tissue such as cells of a cancerous or non-cancerous tumor is disclosed, which involves the placement of electrodes into or near the vicinity of the undesirable tissue through the application of electrical pulses causing irreversible electroporation of the cells throughout the entire area of the desired tissue.
Journal ArticleDOI
Therapy of locally unresectable pancreatic carcinoma: A randomized comparison of high dose (6000 rads) radiation alone, moderate dose radiation (4000 rads + 5‐fluorouracil), and high dose radiation + 5‐fluorouracil. The gastrointestinal tumor study group
Charles G. Moertel,Stephen Frytak,Richard G. Hahn,Michael J. O'Connell,Richard J. Reitemeier,Joseph Rubin,Schutt Aj,Louis H. Weiland,Donald S. Childs,Margaret A. Holbrook,Philip T. Lavin,Elliot M. Livstone,Howard M. Spiro,Arthur H. Knowlton,Martin H. Kalser,Jamie S. Barkin,Howard E. Lessner,R. Mann-Kaplan,Kenneth P. Ramming,H. O. Douglas,Patrick R. M. Thomas,H. Nave,Joseph R. Bateman,Jacob J. Lokich,J. R. V. Brooks,J. Chaffey,Joseph M. Corson,Norman Zamcheck,Joel W. Novak +28 more
TL;DR: One‐hundred‐ninety‐four eligible and evaluable patients with histologically confirmed locally unresectable adenocarcinoma of the pancreas were randomly assigned to therapy with high‐dose radiation therapy alone, to moderate‐dose (4000 rads) radiation + 5‐fluorouracil (5‐FU), and to high‐ dose radiation plus 5‐FU.
Journal ArticleDOI
DPC4 Gene Status of the Primary Carcinoma Correlates With Patterns of Failure in Patients With Pancreatic Cancer
Christine A. Iacobuzio-Donahue,Baojin Fu,Shinichi Yachida,Mingde Luo,Hisashi Abe,Clark M. Henderson,Felip Vilardell,Zheng Wang,Jesse Keller,Priya Banerjee,Joseph M. Herman,John L. Cameron,Charles J. Yeo,Marc K. Halushka,James R. Eshleman,Marian Raben,Alison P. Klein,Ralph H. Hruban,Manuel Hidalgo,Daniel A. Laheru +19 more
TL;DR: Pancreatic cancers are represented by distinct genetic subtypes with significantly different patterns of failure, and determinations of DPC4 status at initial diagnosis may be of value in stratifying patients into treatment regimens related to local control versus systemic therapy.
Journal ArticleDOI
Pretreatment assessment of resectable and borderline resectable pancreatic cancer: expert consensus statement.
Mark P. Callery,Kenneth J. Chang,Elliot K. Fishman,Mark S. Talamonti,L. William Traverso,David C. Linehan +5 more
TL;DR: Patients without distant metastases and no evidence of tumor extension to the SMV and portal vein and clear fat planes around the celiac axis, the hepatic artery, and SMA should be categorized as having localized and resectable cancers.