Is there a role for carbohydrate restriction in the treatment and prevention of cancer
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...…studies also showed that adding insulin to the medium containing high glucose promoted the sequential activation of PI3K, AKT, and mTOR leading to the increased anabolic activity in cancer cells and subsequent 20–40% enhanced proliferation rates (Klement & Kammerer 2011, Ward & Thompson 2012)....
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...…cancer cells: the sweet kiss of death Over the last century, cancer patients have been reported to exhibit signs of early glucose intolerance and insulin insensitivity, most likely as a result of an acute phase inflammatory response induced by the tumor (Marat et al. 1999, Klement & Kammerer 2011)....
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...Free fatty acids and ketone bodies are considered to become a major fuel for normal tissues of cancer patients as a consequence of developing insulin resistance [5]....
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100 citations
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...On the other hand, despite a relatively small amount of data published it appears that the incidence of cancer is also correlated with the increased intake of carbohydrates [21, 22, 23]....
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References
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..., a pathological capability common to most, if not all, cancer cells [39]....
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9,282 citations
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...Inflammation is a wellestablished driver of early tumorigenesis and accompanies most, if not all cancers [148]....
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...As indicated in Figure 2, restriction of dietary CHOs would counteract this signalling cascade by normalizing glucose and insulin levels in subjects with metabolic syndrome, in this way acting similar to calorie restriction/fasting [61,62]....
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