Is there a role for carbohydrate restriction in the treatment and prevention of cancer
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36 citations
Cites background from "Is there a role for carbohydrate re..."
...Diets high in GI result in higher levels of blood glucose and insulin, which promote glucose intolerance, insulin resistance, and hyperinsulinemia (5, 6, 8)....
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...IGFs have been shown to play a critical role in regulating cell proliferation and differentiation in cancer (8) and there is evidence to suggest that IGFs are elevated in lung cancer patients (9, 10)....
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35 citations
Cites background from "Is there a role for carbohydrate re..."
...protect normal tissue from ionizing radiation [1,3]....
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...For example, inflammatory cytokines from the tumor tissue are able to promote insulin resistance, resulting in decreased glucose uptake in peripheral tissues, particularly skeletal muscle, and providing a rationale for a metabolically adapted diet with increased fat content for cancer patients [1,2]....
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35 citations
34 citations
Cites background from "Is there a role for carbohydrate re..."
...enough oxygen is present, which is not the case at those sites where the tumour grows rapidly (29,30)....
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34 citations
References
51,099 citations
"Is there a role for carbohydrate re..." refers background in this paper
..., a pathological capability common to most, if not all, cancer cells [39]....
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9,282 citations
"Is there a role for carbohydrate re..." refers background in this paper
...Inflammation is a wellestablished driver of early tumorigenesis and accompanies most, if not all cancers [148]....
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4,361 citations
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"Is there a role for carbohydrate re..." refers background in this paper
...As indicated in Figure 2, restriction of dietary CHOs would counteract this signalling cascade by normalizing glucose and insulin levels in subjects with metabolic syndrome, in this way acting similar to calorie restriction/fasting [61,62]....
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