Is there a role for carbohydrate restriction in the treatment and prevention of cancer
Citations
760 citations
Cites background from "Is there a role for carbohydrate re..."
...carbohydrate-restricted diets to treat cancer patients have been reported to have therapeutic benefits [84]....
[...]
582 citations
272 citations
255 citations
216 citations
Cites background from "Is there a role for carbohydrate re..."
...Unlike IGFs, local production of insulin by tumors is uncommon (Venkateswaran et al. 2007, Klement & Kammerer 2011)....
[...]
...Notably, IGFs originate from both local and systemic productions in cancer (Fagin et al. 1988, Foulstone et al. 2003) and are commonly expressed by cancer cells (Venkateswaran et al. 2007, Klement & Kammerer 2011)....
[...]
References
204 citations
"Is there a role for carbohydrate re..." refers background in this paper
...Finally, chronic activation of the IGFR1-IR/PI3K/Akt survival pathway through high blood glucose, insulin and inflammatory cytokines has been proposed as a cause of carcinogenesis [30,58,59] and switch towards aerobic glycolysis....
[...]
201 citations
"Is there a role for carbohydrate re..." refers background or result in this paper
...This contrasts with other studies showing growth-inhibitory effects of unrestricted or higher-caloric KDs despite neither decreases in blood glucose concentration nor body weight loss compared with a control group [130,134,135]....
[...]
..., whose diet had been enriched in MCT and omega-3 fatty acids, fat quality might play a role in explaining these results [130]....
[...]
...This stability of blood glucose, independent of ketosis, was subsequently confirmed in studies in which mice were fed ad libitum on a KD [84,114,121-123,130] although two studies reported a drop in blood glucose concentrations compared with the control group [116,131]....
[...]
...NMRI mice 12 23132/87 human gastric adenoma ad libitum 0/14/ 86 cheese + MCT + omega-3 oil 0 > 16 - longer survival ; [130]...
[...]
195 citations
"Is there a role for carbohydrate re..." refers background in this paper
...05), however with no statistically significant effect on tumor latency and weight measured after 10 wk [143]....
[...]
194 citations
"Is there a role for carbohydrate re..." refers background in this paper
...KDs are also used to treat adiposity [118] and currently adult epilepsy [119]....
[...]
192 citations
"Is there a role for carbohydrate re..." refers background in this paper
...Acidification of the microenvironment further induces apoptosis in normal parenchymal and stromal cells [74,75] and therefore provides a strong selective growth advantage for tumor cells that are resistant to low pH-induced apoptosis [76,77]....
[...]