Is there a role for carbohydrate restriction in the treatment and prevention of cancer
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Cites background from "Is there a role for carbohydrate re..."
...carbohydrate-restricted diets to treat cancer patients have been reported to have therapeutic benefits [84]....
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Cites background from "Is there a role for carbohydrate re..."
...Unlike IGFs, local production of insulin by tumors is uncommon (Venkateswaran et al. 2007, Klement & Kammerer 2011)....
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...Notably, IGFs originate from both local and systemic productions in cancer (Fagin et al. 1988, Foulstone et al. 2003) and are commonly expressed by cancer cells (Venkateswaran et al. 2007, Klement & Kammerer 2011)....
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References
151 citations
"Is there a role for carbohydrate re..." refers background in this paper
...demonstrated that glioma cells - although not negatively influenced by b-hydroxybutyrate - are not able to use this ketone body as a substitute for glucose when starved of the latter, contrary to benign neuronal cells [128]....
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...Foxn1nu mice 12 LNT-229 glioma cells ad libitum 0/13/ 36 flaxseed and hempseed oil 1 > 63 - no significant differences in survival, tumor growth and plasma IGF1 levels [128]...
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149 citations
"Is there a role for carbohydrate re..." refers background in this paper
...In the liver, the inflammatory process leads to increased gluconeogenesis that is fuelled by lactate secreted from the tumor as well as glycerol from fatty acid breakdown and the amino acid alanine [106] from muscle proteolysis....
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147 citations
"Is there a role for carbohydrate re..." refers background or result in this paper
...This contrasts with other studies showing growth-inhibitory effects of unrestricted or higher-caloric KDs despite neither decreases in blood glucose concentration nor body weight loss compared with a control group [130,134,135]....
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...observed that a diet rich in corn oil might stimulate prostate cancer growth to a greater extent than one rich in saturated fat [134]....
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...SCID mice 25 LAPC-4 human prostate cancer 9% more energy than control 0/16/ 84 milk fat + lard -24 > 40 ↑ c longer survival b [134]...
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...indeed reported that the mice with the highest levels of ketone bodies had the longest survival times in a human prostate cancer xenograft model [134]....
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146 citations
"Is there a role for carbohydrate re..." refers background in this paper
...In tumor cells, Akt plays a major role in resisting apoptosis and promoting proliferation, and it does so by reprogramming tumor cell metabolism [43-45]....
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...In principle, hyperactivation of this pathway can occur at several points from alterations in either upstream (receptor) or downstream (transducer) proteins and/or disruption of negative feedback loops via loss-of-function mutations in suppressor genes [44,45,54]....
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140 citations