Is there a role for carbohydrate restriction in the treatment and prevention of cancer
Citations
760 citations
Cites background from "Is there a role for carbohydrate re..."
...carbohydrate-restricted diets to treat cancer patients have been reported to have therapeutic benefits [84]....
[...]
582 citations
272 citations
255 citations
216 citations
Cites background from "Is there a role for carbohydrate re..."
...Unlike IGFs, local production of insulin by tumors is uncommon (Venkateswaran et al. 2007, Klement & Kammerer 2011)....
[...]
...Notably, IGFs originate from both local and systemic productions in cancer (Fagin et al. 1988, Foulstone et al. 2003) and are commonly expressed by cancer cells (Venkateswaran et al. 2007, Klement & Kammerer 2011)....
[...]
References
137 citations
"Is there a role for carbohydrate re..." refers background in this paper
...Akt suppresses b-oxidation of fatty acids [46], but enhances de novo lipid synthesis in the cytosol [47,48]....
[...]
137 citations
"Is there a role for carbohydrate re..." refers background in this paper
...Since 1885, when Ernst Freund described signs of hyperglycemia in 70 out of 70 cancer patients [99], it has been repeatedly reported that glucose tolerance and insulin sensitivity are diminished in cancer patients even before signs of cachexia (weight loss) become evident [100-102]....
[...]
129 citations
"Is there a role for carbohydrate re..." refers result in this paper
...This is consistent with stable isotope studies of human fossils [8,9]....
[...]
125 citations
"Is there a role for carbohydrate re..." refers background or result in this paper
.../80 2 MCT emulsion 8 20 ↑ - 50% less weight loss ; left35% less tumor weight [121]...
[...]
...While the diet had no effect on rats bearing the Walker 256 sarcoma [120], it decreased the cachectic weight loss in proportion to its fat content in mice bearing the mousespecific colon carcinoma MAC16 [121]....
[...]
...This stability of blood glucose, independent of ketosis, was subsequently confirmed in studies in which mice were fed ad libitum on a KD [84,114,121-123,130] although two studies reported a drop in blood glucose concentrations compared with the control group [116,131]....
[...]
124 citations
"Is there a role for carbohydrate re..." refers result in this paper
...These results support the epidemiological [25,29,31,32] and in vitro [81,144] findings that high CHO diets, in particular those including high GI foods, promote mammary tumorigenesis via the sustained action of insulin....
[...]