Is there a role for carbohydrate restriction in the treatment and prevention of cancer
Citations
760 citations
Cites background from "Is there a role for carbohydrate re..."
...carbohydrate-restricted diets to treat cancer patients have been reported to have therapeutic benefits [84]....
[...]
582 citations
272 citations
255 citations
216 citations
Cites background from "Is there a role for carbohydrate re..."
...Unlike IGFs, local production of insulin by tumors is uncommon (Venkateswaran et al. 2007, Klement & Kammerer 2011)....
[...]
...Notably, IGFs originate from both local and systemic productions in cancer (Fagin et al. 1988, Foulstone et al. 2003) and are commonly expressed by cancer cells (Venkateswaran et al. 2007, Klement & Kammerer 2011)....
[...]
References
110 citations
"Is there a role for carbohydrate re..." refers background in this paper
...After seven days on the diet, mean body weight had increased by 2 kg and their physical performance status had improved [125]....
[...]
106 citations
"Is there a role for carbohydrate re..." refers background in this paper
...In colorectal [27], prostate [24] and early stage breast cancer patients [23,98] high insulin and low IGFBP-1 levels have been associated with poor prognosis....
[...]
101 citations
"Is there a role for carbohydrate re..." refers background in this paper
...Finally, chronic activation of the IGFR1-IR/PI3K/Akt survival pathway through high blood glucose, insulin and inflammatory cytokines has been proposed as a cause of carcinogenesis [30,58,59] and switch towards aerobic glycolysis....
[...]
...Intriguingly, with the possible exception of Alzheimer’s disease [18], the occurrence and prognosis of cancer seems positively associated with both the prevalence of these diseases [19-28] and the GI and glycemic load (GL) of the diet [29-32]; this implies a possible role of high CHO intake in cancer as well....
[...]
98 citations
"Is there a role for carbohydrate re..." refers background in this paper
...Indeed, it has been shown in healthy subjects that CHO restriction induces hormonal and metabolic adaptions very similar to fasting [63-66]....
[...]
95 citations
"Is there a role for carbohydrate re..." refers background in this paper
...High CHO intake, in particular in the form of sugar and other high GI foods, has been linked to modern diseases like metabolic syndrome [11], Alzheimer’s disease [12,13], cataract and macula degeneration [14-16] and gout [17]....
[...]