Journal ArticleDOI
Isoforms of rat liver fatty acid binding protein differ in structure and affinity for fatty acids and fatty acyl CoAs.
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TLDR
Rat L-FABP isoforms differ markedly in both structure and ligand binding function, and displacement studies indicated that each isoform displayed distinct specificities for fatty acid/fatty acyl CoA chain length and unsaturation.Abstract:
Although native rat liver fatty acid binding protein (L-FABP) is composed of isoforms differing in isoelectric point, their comparative structure and function are unknown. These properties of apo- ...read more
Citations
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Gene networks driving bovine milk fat synthesis during the lactation cycle
Massimo Bionaz,Juan J. Loor +1 more
TL;DR: Results challenge the proposal that SREBF1 is central for milk fat synthesis regulation and highlight a pivotal role for a concerted action among PPARG, PPARGC1A, and INSIG1.
Journal ArticleDOI
New insights into the structure and function of fatty acid-binding proteins.
A W Zimmerman,J H Veerkamp +1 more
TL;DR: A review of recent findings on the diversity of FABPs and their proposed roles in fatty acid (FA) metabolism and other cellular processes focuses on mammalian FABP types.
Journal ArticleDOI
Cellular uptake and intracellular trafficking of long chain fatty acids.
Mark J. McArthur,Barbara P. Atshaves,Andrey Frolov,William D. Foxworth,Ann B. Kier,Friedhelm Schroeder +5 more
TL;DR: The emerging picture is that the cell has multiple, overlapping mechanisms that assure adequate uptake and directed intracellular movement of LCFA required for maintenance of physiological functions.
Journal ArticleDOI
Control of mitochondrial beta-oxidation flux.
TL;DR: The sharing of control between CPTI and other enzymes allows for flexible regulation of metabolism and the ability to rapidly adapt beta-oxidation flux to differing requirements in different tissues.
Journal ArticleDOI
The human fatty acid-binding protein family: evolutionary divergences and functions.
TL;DR: FABPs demonstrate strong evolutionary conservation and are present in a spectrum of species including Drosophila melanogaster, Caenorhabditis elegans, mouse and human, and the most recently identified family member, FABP12, has been less studied.
References
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Journal ArticleDOI
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
TL;DR: This assay is very reproducible and rapid with the dye binding process virtually complete in approximately 2 min with good color stability for 1 hr with little or no interference from cations such as sodium or potassium nor from carbohydrates such as sucrose.
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A Self-Consistent Method for the Analysis of Protein Secondary Structure from Circular Dichroism
TL;DR: A self-consistent procedure for estimating the secondary structure content from circular dichroism spectra of proteins, which finds the Kabsch and Sander protein crystal structure analysis to be most suitable for the prediction method.
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A binding protein for fatty acids in cytosol of intestinal mucosa, liver, myocardium, and other tissues.
TL;DR: A protein of molecular weight ∼ 12,000 which binds long-chain fatty acids and certain other lipids has been identified in cytosol of intestinal mucosa, liver, myocardium, adipose tissue, and kidney and appears to be identical with the smaller of two previously described cytoplasmic anion-binding proteins.
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Brain lipid-binding protein (BLBP): A novel signaling system in the developing mammalian CNS
TL;DR: It is proposed that BLBP is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers.