Isogenic Human iPSC Parkinson’s Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription
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"Isogenic Human iPSC Parkinson’s Mod..." refers background in this paper
...Human epidemiological studies show association of PQ/MB exposure to development of PD (Costello et al., 2009), and this combination causes PD in animal models (Thiruchelvam et al., 2000)....
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4,872 citations
"Isogenic Human iPSC Parkinson’s Mod..." refers background in this paper
...Two categories of cellular events have been uncovered in these studies: (1) protein misfolding, aggregation, and aberrant proteostasis and (2) mitochondrial damage with oxidative/nitrosative stress (Dauer and Przedborski, 2003)....
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4,705 citations
"Isogenic Human iPSC Parkinson’s Mod..." refers background in this paper
...Mitochondrial toxins have been identified in epidemiological studies as contributing to ‘‘sporadic’’ PD, and mitochondrial-based toxin models gained attention following the discovery of MPTP-induced Parkinsonism (Langston et al., 1983)....
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2,713 citations
"Isogenic Human iPSC Parkinson’s Mod..." refers background in this paper
...In addition to ROS, RNS such as nitric oxide (NO) have been linked to mitochondrial stress and can react with critical cysteine residues to affect functional activity via protein S-nitrosylation (forming SNO proteins) (Lei et al., 1992; Lipton et al., 1993; Stamler et al., 1992, 1997)....
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2,478 citations
"Isogenic Human iPSC Parkinson’s Mod..." refers background in this paper
...In addition to ROS, RNS such as nitric oxide (NO) have been linked to mitochondrial stress and can react with critical cysteine residues to affect functional activity via protein S-nitrosylation (forming SNO proteins) (Lei et al., 1992; Lipton et al., 1993; Stamler et al., 1992, 1997)....
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