Journal ArticleDOI
Isolation and preliminary characterization of Escherichia coli mutants resistant to lethal action of the bacteriophage λ P gene
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TLDR
Two types of spontaneous and NTG-induced mutants of Escherichia coli 594 insensitive to the lethal action of λ P gene were isolated and called rpl, showing different phenotypes.About:
This article is published in Virology.The article was published on 1991-05-01. It has received 9 citations till now. The article focuses on the topics: Lambda phage.read more
Citations
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Journal ArticleDOI
Fine Tuning and Cross-talking of TGF-β Signal by Inhibitory Smads
TL;DR: Exploring the molecular mechanisms about the regulations of ISmads may provide the therapeutic clues for human diseases induced by the abnormal TGF-β signaling, which is implicated in the pathogenesis of human diseases.
Journal ArticleDOI
The Bacteriophage λ DNA Replication Protein P Inhibits the oriC DNA- and ATP-binding Functions of the DNA Replication Initiator Protein DnaA of Escherichia coli
TL;DR: It is concluded that the lambda P protein inhibits the binding of oriC DNA and ATP to the wild-type DnaA protein, which causes the inhibition of host DNA synthesis initiation that ultimately leads to bacterial death.
Journal ArticleDOI
Genes that protect against the host-killing activity of the E3 protein of Bacillus subtilis bacteriophage SPO1.
Ping Wei,Charles R. Stewart +1 more
TL;DR: A cloned rpoB gene, specifying an apparently mutantRNA polymerase beta subunit, protected Escherichia coli against the cytocidal effects of the E3 protein of bacteriophage SPO1, suggesting that RNA polymerase is the primary cellular target of theE3 protein.
Journal ArticleDOI
The Mutation that Makes Escherichia coli Resistant to λ P Gene-mediated Host Lethality Is Located within the DNA Initiator Gene dnaA of the Bacterium
Indrani Datta,Sarbani Banik-Maiti,Lopa Adhikari,Subrata Sau,Niranjan Das,Nitai Chandra Mandal +5 more
TL;DR: It is shown that under the lambda P gene-mediated lethal condition, the host DNA synthesis is inhibited at the initiation step, and it is concluded that the rpl mutations, which make E. coli resistant to lambda PGene-mediated host lethality, are located within the DNA initiator gene dnaA of the host.
Journal ArticleDOI
Bacteriophage λ P gene shows host killing which is not dependent on λ DNA replication
TL;DR: It is concluded that the higher levels of P protein, produced either when cro has the hk mutation or when tR1 is deleted, are lethal to the host.
References
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Journal ArticleDOI
Termination Factor for RNA Synthesis
TL;DR: A new protein has been isolated from E. coli which causes specific termination and release of RNA during synthesis in vitro and has been given the name ρ-factor.
Journal ArticleDOI
A new bacterial gene (groPC) which affects lambda DNA replication.
TL;DR: A bacterial mutation affecting λ DNA replication, called groPC756, has been mapped between the thr and leu bacterial loci as mentioned in this paper, and it is shown that the mutation at the groPC locus also interferes with bacterial growth at 42°C.
Journal ArticleDOI
Specialized nucleoprotein structures at the origin of replication of bacteriophage lambda. Protein association and disassociation reactions responsible for localized initiation of replication.
TL;DR: The initiation of lambda DNA replication requires ordered assembly and partial disassembly of specialized nucleoprotein structures, and the disassembly activity of DnaK and DnaJ may be their general role in the heat shock response.
Journal ArticleDOI
A new host gene (groPC) necessary for lambda DNA replication.
TL;DR: The isolation of a bacterial mutation in a gene, designated groPC, which affects the growth of phages lambda and P2, is described and the possibility that the groPC gene is concerned with host DNA replication is discussed.
Journal ArticleDOI
Constitutive λ DNA replication by λc17, a regulatory mutant related to virulence
S. Packman,William S. Sly +1 more
TL;DR: A model is presented that proposes that those λc17 genes which are subject to cI repression in the immune host can be derepressed if phage replication produces too many phage chromosomes for the cI repressor to control.
Related Papers (5)
An Escherichia coli mutant unable to support site-specific recombination of bacteriophage λ
Mutations in bacteriophage lambda repressor that prevent RecA-mediated cleavage.
In vivo and in vitro functional alterations of the bacteriophage lambda receptor in lamB missense mutants of Escherichia coli K-12.
C Braun-Breton,M Hofnung +1 more