Journal ArticleDOI
Isolierung neuer Stoffe aus den Samen der Herbstzeitlose Colchicum autumnale L. Substanzen der Herbstzeitlose und ihre Derivate. 12. Mitteilung
F. Šantavý,T. Reichstein +1 more
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TLDR
Aus den Samen der Herbstzeitlose, Colchicum autumnale L., wurden ausser dem bekannten Colchicin in kleiner Menge noch vier kristallisierte Stoffe isoliert, die als Substanzen B, C, G and I bezeichnet wurden.Abstract:
Aus den Samen der Herbstzeitlose, Colchicum autumnale L., wurden ausser dem bekannten Colchicin in kleiner Menge noch vier kristallisierte Stoffe isoliert, die als Substanzen B, C, G und I bezeichnet wurden.read more
Citations
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Book ChapterDOI
Advances in chemotherapy of cancer in man.
TL;DR: The chapter concludes that the costly lag between discovery in the laboratory or in the clinic and application to the patient with cancer should be abolished or greatly shortened.
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Anti-Microtubule Drugs.
TL;DR: The mechanism by which any MT drug cures or treats any disease is still unsolved, despite decades of research, and solving this problem for particular drug-disease combinations might open new uses for old drugs, or provide insights into novel routes for treatment.
Journal ArticleDOI
History of the use of colchicum and related medicaments in gout; with suggestions for further research.
TL;DR: At the present time colchicine and its derivatives, as well as other mitotic-arresting drugs, are of considerable importance in the field of cancer research, and it is this latter role that concerns us most here.
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Some investigations on cell behavior under various conditions; a review.
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Journal ArticleDOI
Die Konfiguration des Colchicins und verwandter Verbindungen
H. Corrodi,E. Hardegger +1 more
TL;DR: The oxydative abbau von Colchicin mit Ozon and die nachfolgende Oxydation der Ozonisations Produkte mit Perameisensaure fuhrten zu N-Acetyl-Lglutaminsaure as discussed by the authors.
References
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Journal ArticleDOI
Structure of Colchicine
TL;DR: Cohen, Cook and Cook as mentioned in this paper showed that colchicine must be 7-membered, but the exact location of the acetamido group remains uncertain; the isolation by Windaus of 4-methoxyphthalimide from the oxidation product of acetylcolchinol methyl ether suggested that the group was adjacent to ring C, but Lettre and Fernholz3 have found that only β-anisylethylamine derivatives act as mitosis poisons.
Journal ArticleDOI
Effects of colchicine and related substances on cell division
Austin Moore Brues,Aaron Cohen +1 more
TL;DR: The present study has been made in an attempt to determine the effects on mitosis of various compounds derived from colchicine, to assess the importance of the various molecular groupings of col chicine and to determine whether similar mitotic effects may be shown with colchichine derivatives which are devoid of the high toxicity of the parent alkaloid.
Journal ArticleDOI
The effect of hydrogen peroxide in alkaline medium on colchiceine
J. Čech,F. Šantavý +1 more
Journal ArticleDOI
Préparation de l'acide colchicique à partir de la colchicine
TL;DR: In this paper, a part la colchiceine, un acide ineolore C21H23O6N, F. 262-266°, was found.
Journal ArticleDOI
Der mikrochemische Nachweis der Alkaloide in der Pflanze
Gustav Klein,Hermann Sonnleitner +1 more
TL;DR: The sicherste Nachweis last sich durch Destillation mit Kalzium hydroxyd and Nach Weis im Destillat with Dinitro-α-Naphthol erbringen as mentioned in this paper.
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