Journal ArticleDOI
[Joint involvement in chronic inflammatory bowel disease--current diagnostics and treatment options].
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TLDR
Tumor necrosis factor blocking agents may be employed in patients with active disease not responding to conventional treatment, and the emergence of other targets of the inflammatory cascade may provide more treatment choices in the future.Abstract:
Joint involvement is the most frequent extra-intestinal manifestation of chronic inflammatory bowel disease (IBD). Arthralgias are common and spondylarthropathy may affect peripheral joints, the spine as well as tendons. Clinical assessment has the greatest impact on diagnostics and therapy. In particular, a history of "inflammatory back pain" should lead to further investigations. HLA-B27 may be indicative of ankylosing spondylitis in IBD. Ultrasound and magnetic resonance imaging are preferred diagnostic modalities for the assessment of inflammation. Arthralgia often improves during treatment of IBD. In contrast, polyarticular arthritis, sacroiliitis, ankylosing spondylitis and enthesitis often require additional continuous therapy. Baseline therapy includes analgesics, intra-articular corticosteroid administration, and physiotherapy. Disease-modifying antirheumatic drugs such as sulfasalazine and methotrexate are used in polyarticular arthritis. Sulfasalazine may be effective in patients with early axial disease as well. Tumor necrosis factor (TNF) blocking agents may be employed in patients with active disease not responding to conventional treatment. For patients who fail to respond to TNF blockade, the emergence of other targets of the inflammatory cascade may provide more treatment choices in the future.read more
Citations
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Journal ArticleDOI
Whole-body MR imaging for patients with rheumatism.
TL;DR: WB-MRI is not recommended as a first line investigation in every patient suffering from a form of spondyloarthropathy, but may add important information in difficult cases, and might obtain a stronger role in the early diagnosis of sponding, and in the assessment of treatment response.
Journal ArticleDOI
The association of autoimmune diseases with pediatric ulcerative colitis does not influence its disease course
Chloé Guinet-Charpentier,Jacqueline Champigneulle,N Williet,Laurent Peyrin-Biroulet,Alain Morali +4 more
TL;DR: In this pediatric study, CAI had similar characteristics at baseline as CUC and the course of CAI does not seem to be influenced by the presence of concomitant auto-immune diseases.
Journal ArticleDOI
Relationship between articular and nonarticular manifestations in inflammatory bowel diseases.
Alimohammad Fatemi,Hourossadat Hashemi Jazi,Mohammad Hasan Emami,Amir Kazemizadeh,Hamid Tavakkoli,Abbas Smiley +5 more
TL;DR: The most frequent extraintestinal manifestations in patients with IBD were MSM, and knee and ankle were the most frequent involved joints.
DissertationDOI
Schmerzen und Lebensqualität bei Patienten mit chronisch entzündlichenDarmerkrankungen
Journal ArticleDOI
Rheumatologische Manifestationen Chronisch Entzündlicher Darmerkrankungen (CED): Klinik, Diagnostik und therapeutische Optionen
TL;DR: Eine Arthritis, axiale Spondyloarthritis and Enthesitis mussen meist eigenstandig langfristig behandelt werden, in der Bildgebung gewinnt der Einsatz von Arthrosonografie und Magnetresonanztomografies insbesondere in der Fruhdiagnostik an Bedeutung.