KDOQI Clinical Practice Guidelines and Clinical Practice Recommendations for Anemia in Chronic Kidney Disease.
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"KDOQI Clinical Practice Guidelines ..." refers background in this paper
...Caution must be exercised in applying the argets or normal ranges as outlined in the guideine for adult patients with HD-CKD because the ncrease in ferritin target from 100 to 200 ng/mL n adult HD patients is based on evidence to uggest that a level of 100 ng/mL underestimates ron deficiency, and data from a study n which patients with an average serum ferritin evel of 730 ng/mL showed a 40% reduction in SA dose compared with those with an average erritin level of 297 ng/mL.(108) There is no simiar RCT-level evidence for this in children; amely, that achieving a specific ferritin level ill produce a consistent decrease in ESA doses c equired, and there are no adult or pediatric data n the safety of supraphysiological ferritin levls....
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...5 to 13 g/dL how increased access thrombosis compared with lacebo-treated controls,(49) as do patients asigned to a Hb target of 14 g/dL compared with hose assigned to a target of 10 g/dL.(108) Native rteriovenous fistulae fare no better than arteriovenous grafts....
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...Native rteriovenous fistulae fare no better than arteriovenous grafts.(49,108) F o * E a....
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1,288 citations
"KDOQI Clinical Practice Guidelines ..." refers background in this paper
...Although it previously was believed that ecreases in Hb levels might be a consequence of ormal aging, evidence has accumulated that nemia reflects poor health and increased vulnerbility to adverse outcomes in older persons.(32) onsequently, the current recommendation makes o adjustment for aging in men....
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...ent evidence of pathological conditions that ay cause or contribute to anemia.(32) Because we annot exclude potential pathological states, we annot assume that lower Hb levels in older ales are normal....
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1,148 citations
"KDOQI Clinical Practice Guidelines ..." refers background in this paper
...In some atients, anemia may result predominantly from ow endogenous erythropoietin levels and can e corrected readily by administration of ESAs. n other disorders, impaired marrow function, neffective erythropoiesis, and shortened red lood cell survival may contribute to anemia nd ESA hyporesponsiveness....
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...Isolated cases of PRCA have been observed in ssociation with the use of other ESAs.(273,274,276-279) o case of antibody-associated PRCA has been ocumented in patients treated with only IV dministration of ESAs....
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...Long-acting ESAs....
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...Between 1989 and 1998, three eports described the development of PRCA in small number of patients with CKD adminisered ESAs.273,274 Reports of PRCA increased harply in 1998 and reached a peak in 2002 Fig 17).273,275 These reports were associated ith SC administration of an epoetin alfa formuation not available in the United States....
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...Short-acting ESAs....
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854 citations
"KDOQI Clinical Practice Guidelines ..." refers background or methods in this paper
...These include KF-KDOQI Guidelines for Nutrition in KD,(203) previous NKF-KDOQI anemia guideines,(2) and the Revised EBPGs for Anemia in KD.(16) Finally, although oral L-carnitine has also been tudied as an ESA adjuvant, no RCTs are availble....
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...actor for a number of significant adverse patient utcomes, including hospitalizations, CVD, cogitive impairment, and mortality.(16,43-50) Regardess of whether concurrent disorders, if any, are reatable, awareness of their presence is likely to e helpful to the clinician....
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...DOQI Guidelines for Anemia(2) and the most ecent (2004) version of the European Best Pracices Guidelines (EBPGs) for anemia (Fig 2).(16) Fig 2....
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...The Hct result is derived indiectly by automated analyzers and is instrumenation dependent.(16) Analytical advantages of Hb evel over Hct are described next....
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