Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4.
Citations
65 citations
Cites background from "Keeping p53 in check: essential and..."
...Indeed, inhibition of p53 by direct binding seems to be the principal mechanism by which MDMX – the ubiquitin ligase-defective sister of MDM2 – is thought to function [26]....
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64 citations
63 citations
Cites background from "Keeping p53 in check: essential and..."
...In contrast, multiple studies have shown that the absence of the key negative regulators of p53, MDM2 and MDM4, in embryos results in early embryonic lethality, which is rescued by knocking out the p53 gene (8, 36)....
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...This lethal phenotype can be rescued by knocking out the p53 gene (36)....
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63 citations
Cites background from "Keeping p53 in check: essential and..."
...Rather, consistent with other analyses, we postulate that the more critical regulatory targets in the p53 system are its negative regulators Mdm2 and Mdm4 (MdmX) and the various factors that control their abundance, stability, interactions with p53, and subcellular locations (13, 20, 28, 29)....
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62 citations
Cites background from "Keeping p53 in check: essential and..."
...an E3 ubiquitin ligase, regulates p53 by controlling both the stability of the p53 protein and the activity of p53 as a transcription factor (1)....
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References
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