Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4.
Citations
52 citations
Cites background from "Keeping p53 in check: essential and..."
...It is widely appreciated the p53-MDM2 interaction is an important determinant of the steady-state levels of p53 protein [155]....
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...Further, downstream p53 signaling events are dependent on the disruption of the physical interaction between these two proteins [155]....
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52 citations
Cites background from "Keeping p53 in check: essential and..."
...MDM2 functions as an E3 ubiquitin ligase responsible for the degradation of p53 (6), whereas MDM4, a homolog of MDM2, appears to inhibit p53 by masking its transcriptional activation domain (7)....
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51 citations
50 citations
Cites background from "Keeping p53 in check: essential and..."
...physiological conditions, p53 protein levels are very low because of MDM2-dependent proteasomal degradation.(11)...
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...At higher levels, the activity of MDM2 results in polyubiquitination and subsequent proteasomal degradation of p53.(11,16,17) Third, MDM2 also induces monoubiquitination...
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49 citations
References
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