Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4.
Citations
36 citations
36 citations
Cites background from "Keeping p53 in check: essential and..."
...The Mdm2 oncoprotein is a key regulator of the p53 response (Marine et al., 2006), and studies identified JMY as a new target through which Mdm2 regulates p53 activity (Coutts et al....
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...The Mdm2 oncoprotein is a key regulator of the p53 response (Marine et al., 2006), and studies identified JMY as a new target through which Mdm2 regulates p53 activity (Coutts et al., 2007)....
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36 citations
Cites background from "Keeping p53 in check: essential and..."
...Mdm2 regulates p53 levels by targeting p53 for ubiquitin-mediated degradation (46)....
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35 citations
Cites background from "Keeping p53 in check: essential and..."
...Challenged with stress signals such as hypoxia or DNA damage, the feedback loop of Mdm2-p53 is disturbed, leading to apoptosis or malignancy (Marine et al., 2006)....
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34 citations
Additional excerpts
...activity rather than its stability (28)....
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References
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