Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4.
Citations
33 citations
Cites background from "Keeping p53 in check: essential and..."
...More specifically, MDMX affects p53 abundance by modulating the levels and activity of MDM2; MDMX also binds to the transactivation domain of p53 and inhibits p53 transcriptional activity, which contributes to the overall inhibition of p53 (Toledo and Wahl, 2006; Marine et al., 2006)....
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...Given the important role that MDMX plays in the p53 pathway (Toledo and Wahl, 2006; Marine et al., 2006), it is highly desirable to incorporate MDMX into a computational model....
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...Figure 1 depicts a block diagram of the model for the p53-MDM2/MDMX loop (Toledo and Wahl, 2006; Marine et al., 2006)....
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33 citations
Cites background from "Keeping p53 in check: essential and..."
...The protein also undergoes various posttranslational modifications, which notably affect its activity, and the most prominent negative regulator of p53 is the MDM2 (Mouse double minute 2 homolog) protein [15,16]....
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33 citations
Cites background from "Keeping p53 in check: essential and..."
...Importantly, these data confirmed previous genetic evidence that optimal p53 reactivation can only be achieved by targeting both MDM proteins simultaneously (16) and therefore highlighted the need of identifying molecules that target both the p53-MDM2 and p53-MDM4 interactions....
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32 citations
32 citations
Cites background from "Keeping p53 in check: essential and..."
...genetic studies support the notion that the major physiological importance of Mdm2 relates to its ability to regulate p53 protein abundance and that Mdm2 has little effect on p53 transcriptional activity on a “per molecule” basis (reviewed in [84])....
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References
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