Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4.
Citations
27 citations
Cites background from "Keeping p53 in check: essential and..."
...Mdm2 or the human homologue of murine double minute 2 is an E3-ubiquitin ligase that binds the transcriptional activation domain of p53 and blocks its ability to regulate target genes and sustain antioncogenic effects, leading to increased and uncontrolled cell proliferation, and malignant transformation [34,72,73]....
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27 citations
Cites background from "Keeping p53 in check: essential and..."
...Since its discovery in the early 90’s, the feedback loop is considered the major pathway necessary for regulating the post-stress levels and activity of p53 in a cell [6, 11-13]....
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27 citations
26 citations
Cites background from "Keeping p53 in check: essential and..."
...In normally proliferating cells, p53 is tightly controlled by the function of its main regulators, MDM2 (mouse double minute 2) and MDM4 proteins, which perform non-redundant activities [22]....
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26 citations
Cites background from "Keeping p53 in check: essential and..."
...In simple terms, once bound, Mdm2 inhibits p53 activity by blocking transcription and targeting it for degradation [26, 27]....
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References
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