Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4.
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Cites background from "Keeping p53 in check: essential and..."
...MDM2 and MDMX are predominantly found as heterodimers, which is thought to enhance E2 protein recruitment and stabilize the ternary complex containing tumor protein p53 (best known as p53).(6) In our study, we found that MDMX enhances the ability of MDM2 to bind to and promote RB degradation....
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...As an important alternative pathway to inactivate p53 in addition to p53 gene mutations, amplification of MDM2 or MDMX genes is found in a variety of human tumors and cancers.(6) Of note, the MDMX gene is amplified in more than 60% of human retinoblastomas, with an additional 10% of retinoblastomas exhibiting MDM2 gene amplification....
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10 citations
10 citations
Cites background from "Keeping p53 in check: essential and..."
...MDM2 and MDM4 have synergistic functions in TP53 regulation; both can interact directly with TP53 and inhibit its activity either by promoting its degradation or repressing its transcriptional activation domain.(4) MDM4 is a bona fide oncogene amplified in a subset of colorectal carcinomas, glioblastomas and retinoblastomas....
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9 citations
9 citations
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