Ketamine Treatment and Global Brain Connectivity in Major Depression
Chadi G. Abdallah,Lynnette A. Averill,Katherine A. Collins,Paul Geha,Jaclyn Schwartz,Christopher L. Averill,Kaitlin E. DeWilde,Edmund Wong,Alan Anticevic,Cheuk Y. Tang,Dan V. Iosifescu,Dennis S. Charney,James W. Murrough +12 more
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TLDR
The extent of the functional dysconnectivity identified in MDD and the swift and robust normalization following treatment suggest that GBCr may serve as a treatment response biomarker for the development of rapid acting antidepressants.About:
This article is published in Neuropsychopharmacology.The article was published on 2017-05-01 and is currently open access. It has received 236 citations till now. The article focuses on the topics: Prefrontal cortex & Posterior cingulate.read more
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Journal ArticleDOI
Altered connectivity in depression: GABA and glutamate neurotransmitter deficits and reversal by novel treatments
TL;DR: These studies demonstrate that depression and chronic stress exposure cause atrophy of neurons in cortical and limbic brain regions implicated in depression, and brain imaging studies demonstrate altered connectivity and network function in the brains of depressed patients.
Journal ArticleDOI
Targeting glutamate signalling in depression: progress and prospects
TL;DR: The glutamate N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine was recently repurposed as a rapidly acting antidepressant, catalysing the vigorous investigation of glutamate-signalling modulators as novel therapeutic agents for depressive disorders.
Journal ArticleDOI
Resting state brain network function in major depression - Depression symptomatology, antidepressant treatment effects, future research.
Janis Brakowski,Simona Spinelli,Nadja Dörig,Oliver G. Bosch,Andrei Manoliu,Martin Grosse Holtforth,Erich Seifritz +6 more
TL;DR: It appears clear that functional connectivity alterations are associated with the pathophysiology and treatment of MDD, and future research should also generate a common strategy for data acquisition and analysis to set the basis for comparability across studies and implementation of functional connectivity as a scientifically and clinically useful biomarker.
Journal ArticleDOI
Lower synaptic density is associated with depression severity and network alterations.
Sophie E. Holmes,Dustin Scheinost,Sjoerd J. Finnema,Mika Naganawa,Margaret T. Davis,Nicole DellaGioia,Nabeel Nabulsi,David Matuskey,Gustavo A. Angarita,Robert H. Pietrzak,Robert H. Pietrzak,Ronald S. Duman,Gerard Sanacora,John H. Krystal,John H. Krystal,Richard E. Carson,Irina Esterlis,Irina Esterlis +17 more
TL;DR: This is the first in vivo evidence linking lower synaptic density to network alterations and symptoms of depression, and provides further incentive to evaluate interventions that restore synaptic connections to treat depression.
Journal ArticleDOI
Ketamine: A Paradigm Shift for Depression Research and Treatment
TL;DR: Neurobiological insights into ketamine efficacy shed new light on the mechanisms underlying antidepressant efficacy.
References
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TL;DR: The response and remission rates in this highly generalizable sample with substantial axis I and axis III comorbidity closely resemble those seen in 8-week efficacy trials.
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A Randomized Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Major Depression
Carlos A. Zarate,Jaskaran Singh,Paul J. Carlson,Nancy E. Brutsche,Rezvan Ameli,David A. Luckenbaugh,Dennis S. Charney,Husseini K. Manji +7 more
TL;DR: Robust and rapid antidepressant effects resulted from a single intravenous dose of an N-methyl-D-aspartate antagonist; onset occurred within 2 hours postinfusion and continued to remain significant for 1 week.
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Large-scale brain networks and psychopathology: a unifying triple network model
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Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression
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