Key nodes of a microRNA network associated with the integrated mesenchymal subtype of high-grade serous ovarian cancer.
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Cites background from "Key nodes of a microRNA network ass..."
...In addition to anti-metastatic miRNAs, a number of miRNAs are pro-metastatic such as miR-21, miR-373 and miR-520c (42,43)....
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Cites background from "Key nodes of a microRNA network ass..."
...MicroRNA (miRNA) is a kind of endogenous noncoding small RNA of approximately 18 to 25 nt in length, which is involved in regulating physiological processes such as cell growth, proliferation, differentiation, and apoptosis.(17) Current studies have found that miRNA is also involved in the formation of a variety of tumors, such as those in the neck, lung, lymph, breast, prostate, colorectal, and other parts, and is expected to be a new entry point for drug resistance alleviation....
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References
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"Key nodes of a microRNA network ass..." refers methods in this paper
...Using a large-scale miRnome analysis, Volinia et al.[136] measured 540 different malignant tumor samples and found that the expression of miR-128b was significantly up-regulated in tumor tissues of the colon, lung, and pancreas....
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...Using a large-scale miRnome analysis, Volinia et al.([136]) measured 540 different malignant tumor samples and found that the expression of miR-128b was significantly up-regulated in tumor tissues of the colon, lung, and pancreas....
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5,609 citations
3,640 citations
"Key nodes of a microRNA network ass..." refers background in this paper
...Our group has provided evidence that miR-101 suppresses EMT in ovarian cancer by directly targeting the E-cadherin suppressor genes zinc finger E-box binding homeobox 1 (ZEB1) and ZEB2 via specific binding sites on their 3-UTRs[52]....
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...By contrast, the overexpression of signal transducer and activator of transcription 3 (Stat3) [75], platelet-derived growth factor D (PDGF-D)[76], Notch1[77], and doublecortin-like kinase 1 (DCLK1)[78] in cancer cells led to a significant down-regulation of miR-200 family members, resulting in the up-regulation of ZEB1, ZEB2, and SNAI2 expression and acquisition of the EMT phenotype....
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...Recent studies reported that the miR-200 family plays a critical role in suppressing EMT as well as cancer invasion and metastasis by targeting transcriptional repressors of ZEB1 and ZEB2[68]....
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...Furthermore, ZEB1 and ZEB2 repress the expression of miR-200a and miR-141[69] by binding to a conserved pair of ZEB-type E-box elements proximal to the transcription start site in the promoter region[70]....
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...Recent studies reported that the miR-200 family plays a critical role in suppressing EMT as well as cancer invasion and metastasis by targeting transcriptional repressors of ZEB1 and ZEB2([68])....
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1,912 citations