Kinetics of Dimethylamine Nitrosation in Relation to Nitrosamine Carcinogenesis
01 Mar 1970-Journal of the National Cancer Institute (Oxford University Press)-Vol. 44, Iss: 3, pp 633-639
About: This article is published in Journal of the National Cancer Institute.The article was published on 1970-03-01. It has received 145 citations till now. The article focuses on the topics: Dimethylamine & Nitrosation.
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723 citations
TL;DR: The formation of carcinogenic N-nitroso compounds by the chemical reaction between nitrous acid and oxytetracycline, morpholine, piperazine, N-methylaniline, methylurea, and (in some experiments) dimethylamine was blocked by ascorbic acid.
Abstract: The formation of carcinogenic N-nitroso compounds by the chemical reaction between nitrous acid and oxytetracycline, morpholine, piperazine, N-methylaniline, methylurea, and (in some experiments) dimethylamine was blocked by ascorbic acid. The extent of blocking depended on the compound nitrosated and on the experimental conditions. Urea and ammonium sulfamate were less effective as blocking agents. The possibility of in vivo formation of carcinogenic N-nitroso compounds from drugs could be lessened by the combination of such drugs with the ascorbic acid.
500 citations
TL;DR: The status of knowledge of nitrosamines is reviewed to gain perspective and to distinguish between actual and potential occurrence of these compounds or their formation in vivo (or both).
Abstract: The potential hazards of nitrosamines as toxicants formed in, or as a result of eating, certain foodstuffs have been described in newspapers (1), in testimony before congressional committees (2), in technical articles (3), and in consumer publications (4). We believe it appropriate therefore to review the status of knowledge of these substances to gain perspective and to distinguish between actual and potential occurrence of these compounds or their formation in vivo (or both). Some authors have carried out test tube reactions between nitrite and secondary amines and have indicated that these precursor substances are components of a number of foods we eat or drugs we take (5). However, it does not necessarily follow that by either in vitro or in vivo mechanisms we are being exposed to nitrosamines from a variety of sources. Evidence for the presence or formation of nitrosamines in foods is limited and some of the earlier reports of nitrosamines in human nutrients may have been based on inadequate analytical procedures (6). Furthermore, because pharnmacological data on the action of various nitrosamines are incomplete at
420 citations
TL;DR: It is concluded that protein modifications, and particularly phenol and thiol oxidation, may be an important mechanism, as well as initiation of lipid peroxidation, of action of NO2.
314 citations
TL;DR: This critical review addresses the atmospheric gas phase and aqueous phase amine chemistry that is relevant to potential emissions from amine-based carbon capture and storage (CCS).
Abstract: This critical review addresses the atmospheric gas phase and aqueous phase amine chemistry that is relevant to potential emissions from amine-based carbon capture and storage (CCS) The focus is on amine, nitrosamine and nitramine degradation, and nitrosamine and nitramine formation processes A comparison between the relative importance of the various atmospheric sinks for amines, nitrosamines and nitramines is presented
242 citations