Journal ArticleDOI
Krebs cycle: activators, inhibitors and their roles in the modulation of carcinogenesis
Amin Gasmi,Massimiliano Francesco Peana,Maria Arshad,Monica Butnariu,Alain Menzel,Geir Bjørklund +5 more
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TLDR
In this article, a review of metabolic properties of cancer cells is presented, focusing on the main nutritional substrates, such as glucose and glutamine, evaluating lactate dehydrogenase as a potential marker of malignancy and estimating activators and inhibitors in cancer treatment.Abstract:
A fundamental metabolic feature of cancerous tissues is high glucose consumption. The rate of glucose consumption in a cancer cell can be 10-15 times higher than in normal cells. Isolation and cultivation of tumor cells in vitro highlight properties that are associated with intensive glucose utilization, the presence of minimal oxidative metabolism, an increase in lactate concentrations in the culture medium and a reduced rate of oxygen consumption. Although glycolysis is suggested as a general feature of malignant cells and recently identified as a possible contributing factor to tumor progression, several studies highlight distinct metabolic characteristics in some tumors, including a relative decrease in avidity compared to glucose and/or a glutamine dependency of lactate and even proliferative tumor cells. The aim of this review is to determine the particularities in the energy metabolism of cancer cells, focusing on the main nutritional substrates, such as glucose and glutamine, evaluating lactate dehydrogenase as a potential marker of malignancy and estimating activators and inhibitors in cancer treatment.read more
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An updated overview on metal nanoparticles toxicity
TL;DR: In this article, the authors discuss the origin, behavior and biological toxicity of different metal nanoparticles with the aim of rationalizing related health hazards and calling attention to toxicological concerns involved in their increasingly widespread use.
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Thioredoxin reductase as a pharmacological target.
TL;DR: The pieces of evidence presented here justify why TrxR is recognized as one of the most critical clinical targets and the growing current interest in developing molecules capable of interfering with the functions of TrXR enzymes.
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Dihydroartemisinin mediating PKM2-caspase-8/3-GSDME axis for pyroptosis in esophageal squamous cell carcinoma.
Mingxia Jiang,Yiming Wu,Ling Qi,Lisha Li,Dongfeng Song,Junqing Gan,Yanjing Li,Xiaodong Ling,Chengxin Song +8 more
TL;DR: In this paper, the exact mechanism by which DHA induces pyroptosis to inhibit esophageal squamous cell carcinoma (ESCC) remains unclear, but DHA treatment was applied to ESCC cells and some dying cells exhibited the characteristic morphology of pyroPTosis, such as blowing large bubbles from the cell membrane, accompanied by downregulation of pyruvate kinase isoform M2 (PKM2), activation of caspase-8/3, and production of GSDME-NT.
Journal ArticleDOI
Astaxanthin overproduction of Phaffia rhodozyma PR106 under titanium dioxide stress by transcriptomics and metabolic regulation analysis.
Jing Zhang,Qingru Li,Yanhong Lu,Xiaoyu Guan,Jiahuan Liu,Na Xu,Chunyu Cai,Xia Li,Bo Nan,Jingsheng Liu,Wang Yuhua +10 more
TL;DR: In this article, the authors showed that the increase in astaxanthin yield of Phaffia rhodozyma PR106 increased significantly under titanium dioxide (TiO2) stress and the yield of lycopene and β-carotene also increased significantly.
Journal ArticleDOI
Biological Effects of Human Exposure to Environmental Cadmium
Massimiliano Francesco Peana,Alessio Pelucelli,Christos T. Chasapis,Spyros P. Perlepes,Vlasoula Bekiari,Serenella Medici,Maria Antonietta Zoroddu +6 more
TL;DR: In this paper , exposure and potential health concerns due to environmental cadmium exposure are considered, and a total of 12 cancer types associated with specific genes coding for the Cd-metalloproteome were identified.
References
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Journal ArticleDOI
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
TL;DR: It is proposed that the metabolism of cancer cells, and indeed all proliferating cells, is adapted to facilitate the uptake and incorporation of nutrients into the biomass needed to produce a new cell.
Journal ArticleDOI
The Warburg Effect: How Does it Benefit Cancer Cells?
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Journal ArticleDOI
Management of Hyperglycemia in Type 2 Diabetes, 2015: A Patient-Centered Approach: Update to a Position Statement of the American Diabetes Association and the European Association for the Study of Diabetes
Silvio E. Inzucchi,Richard M. Bergenstal,John B. Buse,Michaela Diamant,Ele Ferrannini,Michael A. Nauck,Anne L. Peters,Apostolos Tsapas,Richard C. Wender,David R. Matthews +9 more
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Journal ArticleDOI
Succinate is an inflammatory signal that induces IL-1β through HIF-1α
Gillian M. Tannahill,Anne M. Curtis,Juraj Adamik,Eva M. Palsson-McDermott,Anne F. McGettrick,Gautam Goel,Christian Frezza,Nicholas J. Bernard,Beth Kelly,Niamh Foley,Liang Zheng,A. Gardet,Zhen Tong,S. S. Jany,Sinéad C. Corr,Moritz Haneklaus,Brian E. Caffrey,Kerry A. Pierce,Sarah R. Walmsley,F. C. Beasley,Eoin P. Cummins,Victor Nizet,Moira K. B. Whyte,Cormac T. Taylor,Hening Lin,Seth L. Masters,Eyal Gottlieb,Vincent P. Kelly,Clary B. Clish,Philip E. Auron,Ramnik J. Xavier,Ramnik J. Xavier,Luke A. J. O'Neill +32 more
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Metformin and reduced risk of cancer in diabetic patients
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