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Proceedings ArticleDOI

Label Free Identification of Glucose Using Flexible SERS Platforms

TL;DR: In this article, metal assisted chemical etched Si nanostructures have been transferred onflexible sheets (adhesive tape) followed by deposition of Au/Ag nanoparticles to make SERS active platform.
Abstract: Metal assisted chemical etched Si nanostructures have been transferred onflexible sheets (adhesive tape) followed by deposition of Au/Ag nanoparticles to make SERS active platform. It shows significant enhancement of Raman signal of glucose in the vicinity of metal nanoparticles due to its coupling with the surface plasmon of nanostructures. SERS detection of glucose is extremely difficult because of its weak Raman cross section and poor adsorption to metal NPs. Fabricated SERS platform was utilized to detect glucose without any label at low concentration 10 micro molar (µM). The developed cost-effective SERS platform has potential applications as a platform device for non-invasive, label free detection of glucose in human fluid for point of care applications.
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Journal ArticleDOI
01 Oct 2022
TL;DR: In this article , the contemporary developments in the utilization of Si nanostructures and nanocomposites for antibacterial surfaces and theranostic agents as powerful instruments to tackle pathogenic bacteria and diseases related to them.
Abstract: Silicon (Si) nanomaterials are extensively explored to address the multidrug resistance bacteria/diseases and to enable developments of novel and innovative approaches for next-generation highly efficient, cost-effective, and reliable multifunctional biomedical tools. This article reviews the contemporary developments in the utilization of Si nanostructures (Si-NSs) and nanocomposites for antibacterial surfaces and theranostic agents as powerful instruments to tackle pathogenic bacteria and diseases related to them. Realization of nature-inspired antibacterial surfaces, photoresponsive smart antibacterial surfaces, and selective functionality of Si-NSs has been discussed by biomedical imaging and drug delivery applications of Si-NSs. Photoresponsive Si nanocomposite systems enable in-situ non-invasive process monitoring utilizing surface-enhanced Raman spectroscopy (SERS) or photothermal imaging phenomenon is also addressed. Finally, crucial challenges and several research trends of implementing Si-NSs and their hybrid systems as multifunctional platforms for advanced biomedical tools and their clinical translation are highlighted.

2 citations

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Journal Article

28,685 citations


"Label Free Identification of Glucos..." refers background in this paper

  • ...Other methods also experience several limitation as they based on same principle of proteinmediated binding of glucose [4]....

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Journal ArticleDOI
Yujun Song1, Konggang Qu1, Chao Zhao1, Jinsong Ren1, Xiaogang Qu1 
TL;DR: A simple, cheap, and highly sensitive and selective colorimetric method for glucose detection has been developed and will facilitate the utilization of GO-COOH intrinsic peroxidase activity in medical diagnostics and biotechnology.
Abstract: Carboxyl-modified graphene oxide (GO-COOH) possesses intrinsic peroxidase-like activity that can catalyze the reaction of peroxidase substrate 3,3,5,5-tetramethyl-benzidine (TMB) in the presence of H2O2 to produce a blue color reaction. A simple, cheap, and highly sensitive and selective colorimetric method for glucose detection has been developed and will facilitate the utilization of GO-COOH intrinsic peroxidase activity in medical diagnostics and biotechnology.

1,763 citations


"Label Free Identification of Glucos..." refers methods in this paper

  • ..., electrochemistry [1], colorimetry [2] and fluorescence [3] methods....

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Journal ArticleDOI
TL;DR: This work presents the first step toward a glucose biosensor using surface-enhanced Raman spectroscopy (SERS) using leave-one-out partial least-squares (LOO-PLS) analysis to demonstrate quantitative glucose detection both over a large and clinically relevant concentration range.
Abstract: This work presents the first step toward a glucose biosensor using surface-enhanced Raman spectroscopy (SERS). Historically, glucose has been extremely difficult to detect by SERS because it has a small normal Raman cross section and adsorbs weakly or not at all to bare silver surfaces. In this paper, we report the first systematic study of the direct detection of glucose using SERS. Glucose is partitioned into an alkanethiol monolayer adsorbed on a silver film over nanosphere (AgFON) surface and thereby, it is preconcentrated within the 0-4 nm thick zone of electromagnetic field enhancement. The experiments presented herein utilize leave-one-out partial least-squares (LOO-PLS) analysis to demonstrate quantitative glucose detection both over a large (0-250 mM) and clinically relevant (0-25 mM) concentration range. The root-mean-squared error of prediction (RMSEP) of 1.8 mM (33.1 mg/dL) in the clinical study is near that desired for medical applications (1 mM, 18 mg/dL). Future studies will advance toward true in vivo, real time, minimally invasive sensing.

627 citations

Journal ArticleDOI
TL;DR: This paper serves as a comprehensive review, where for selected 14 carbohydrates in the solid state both FT-Raman and ATR FT-IR spectra were collected and assigned and marker bands of the studied molecules can be identified and correlated with their structure.

573 citations

Journal ArticleDOI
TL;DR: This review presents a basic theory and illustrates the way in which SERS/SERRS has been developed for practical use.
Abstract: Surface-enhanced Raman scattering (SERS) and surface-enhanced resonance Raman scattering (SERRS) can provide positive identification of an analyte or an analyte mixture with high sensitivity and selectivity. Better understanding of the theory and advances in the understanding of the practice have led to the development of practical applications in which the unique advantages of SERS/SERRS have been used to provide effective solutions to difficult analytical problems. This review presents a basic theory and illustrates the way in which SERS/SERRS has been developed for practical use.

525 citations