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Lactococcal bacteriocins - mode of action and immunity

Koen Venema, +2 more
- 01 Aug 1995 - 
- Vol. 3, Iss: 8, pp 299-304
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TLDR
The lactococcal bacteriocins are hydrophobic cationic peptides, which form pores in the cytoplasmic membrane of sensitive cells.
About
This article is published in Trends in Microbiology.The article was published on 1995-08-01 and is currently open access. It has received 78 citations till now. The article focuses on the topics: Bacteriocin & Antimicrobial peptides.

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Citations
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Development, optimization and scale up of the production and purification process of bacteriocins from lactic acid bacteria

TL;DR: In this paper, the authors propose a method to improve the accuracy of the 3.4.4-score, i.e., 2.5.0.0-0.
Journal Article

Prevalence of bacteriocin activities and bacteriocin encoding genes in enterococcal clinical isolates of Iran

TL;DR: This work is the first survey on the prevalence of bacteriocin genes among clinical enterococci in Iran that has isolated a strain with high antimicrobial activity and sensitivity to clinically relevant antibiotics.
References
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Journal ArticleDOI

Genetics of bacteriocins produced by lactic acid bacteria

TL;DR: The biochemical and genetic characteristics of these antimicrobial proteins are reviewed and common elements are discussed between the different classes of bacteriocins produced by these Gram-positive bacteria.
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Bacteriocins of lactic acid bacteria

TL;DR: The range of inhibitory activity by bacteriocins of lactic acid bacteria can be either narrow, inhibiting only those strains that are closely related to the producer organism, or wide, inhibited a diverse group of Gram-positive microorganisms as mentioned in this paper.
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Nisin treatment for inactivation of Salmonella species and other gram-negative bacteria.

TL;DR: It is demonstrated that nisin is bactericidal to Salmonella species and that the observed inactivation can be demonstrated in other gram-negative bacteria.
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Characterization of the nisin gene cluster nisABTCIPR of Lactococcus lactis. Requirement of expression of the nisA and nisI genes for development of immunity

TL;DR: Transcription analyses of several L. lactis strains indicated that an expression product of the nisA gene, together with NisR, is required for the activation of nisinA transcription, indicating that NisI plays a role in the immunity mechanism.
Journal ArticleDOI

Mode of action of the peptide antibiotic nisin and influence on the membrane potential of whole cells and on cytoplasmic and artificial membrane vesicles

TL;DR: The data suggest that the cytoplasmic membrane is the primary target and that membrane disruption accounts for the bactericidal action of nisin.
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