Lactoferrin-tethered betulinic acid nanoparticles promote rapid delivery and cell death in triple negative breast and laryngeal cancer cells.
Asim Halder,Megha Jethwa,Pritha Mukherjee,Subarna Ghosh,Suvadra Das,A. B. M. Helal Uddin,Arup Mukherjee,Urmi Chatterji,Partha Roy +8 more
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TLDR
Lf-BAnp demonstrated strong anti-proliferative and cytotoxic effects, along with increased sub-G1 population and reduced number of cells in G1 and G2/M phases of the cell cycle, confirming reduced cell proliferation and significant cell death.Abstract:
Cancer management presents multifarious problems. Triple negative breast cancer (TNBC) is associated with inaccurate prognosis and limited chemotherapeutic options. Betulinic acid (BA) prevents ang...read more
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Recent advances in phytochemical-based Nano-formulation for drug-resistant Cancer
Mahesh P. More,Sagar R. Pardeshi,Chandrakantsing V. Pardeshi,Gaurav A. Sonawane,Mahesh N. Shinde,Prashant K. Deshmukh,Jitendra Naik,Abhijeet D Kulkarni +7 more
TL;DR: The present review highlights the phytochemical based nanoformulations in improving the therapeutic response and several alternative ways to target resistance cancer.
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Enhancement of blood-brain barrier penetration and the neuroprotective effect of resveratrol.
Nikita Katila,Ramesh Duwa,Sunil Bhurtel,Shristi Khanal,Srijan Maharjan,Jee-Heon Jeong,Sooyeun Lee,Dong-Young Choi,Simmyung Yook +8 more
TL;DR: In this paper , RSV-loaded PLGA nanoparticles were conjugated with lactoferrin (Lf) to enhance RSV diffusion into the brain and assessed whether this formulation improved the neuroprotective effects of RSV in experimental PD models.
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Nanoformulations for Delivery of Pentacyclic Triterpenoids in Anticancer Therapies.
TL;DR: In this paper, the authors demonstrate the high antitumor potential of systems for delivery of pentacyclic triterpenoids, characterized by six-and five-membered ring structures, are one of the largest class of natural metabolites sourced from the plant kingdom.
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A hydrogen peroxide responsive resorufin-based phototheranostic agent for selective treatment of cancer cells
TL;DR: In this article, a hydrogen peroxide (H2O2) activatable iodinated resorufin (RR-1) was introduced as a red-shifted, water soluble and cancer cell selective photosensitizer, which exhibited high singlet oxygen quantum yield in aqueous solutions upon reacting with H2O 2 and induced selective photocytotoxicity in colorectal (HCT-116) and triple negative breast (MDA MB-231) cancer cells.
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Betulinic acid: A natural promising anticancer drug, current situation, and future perspectives
Maniyamma Aswathy,Ajesh Vijayan,Uzini Devi Daimary,Sosmitha Girisa,Kokkuvayil Vasu Radhakrishnan,Ajaikumar B. Kunnumakkara +5 more
TL;DR: The current review delineates the mechanistic framework of BA-mediated cancer suppression through the modulation of multiple signaling pathways and also summarizes the key outcomes of BA in preclinical investigations.
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