Laminin Interactions Important for Basement Membrane Assembly Are Promoted by Zinc and Implicate Laminin Zinc Finger-like Sequences
John B. Ancsin,Robert Kisilevsky +1 more
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It is reported here that Zn can influence laminin binding activity, in vitro and Zn-laminin complexes may generate high affinity binding sites which contribute to BM cross-linking important for its assembly and homeostasis.About:
This article is published in Journal of Biological Chemistry.The article was published on 1996-03-22 and is currently open access. It has received 49 citations till now. The article focuses on the topics: Laminin binding & Laminin.read more
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Basement membranes: structure, assembly and role in tumour angiogenesis
TL;DR: The basement membrane (BM) as mentioned in this paper is a specialized form of extracellular matrix (ECM) which mediates tissue compartmentalization and sends signals to epithelial cells about the external microenvironment.
Journal ArticleDOI
Serum amyloid A, the major vertebrate acute-phase reactant.
TL;DR: Although the precise role of A-SAA in host defense during inflammation has not been defined, many potential clinically important functions have been proposed for individual SAA family members, including involvement in lipid metabolism/transport, induction of extracellular-matrix-degrading enzymes, and chemotactic recruitment of inflammatory cells to sites of inflammation.
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Zinc Metabolism in the Brain: Relevance to Human Neurodegenerative Disorders ☆
Math P. Cuajungco,G.J. Lees +1 more
TL;DR: Increased levels of chelatable zinc have been shown to be present in cell cultures of immune cells undergoing apoptosis, very reminiscent of the zinc staining of neuronal perikarya dying after an episode of ischemia or seizure activity.
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Zinc takes the center stage: its paradoxical role in Alzheimer's disease.
Math P. Cuajungco,Kyle Y. Fagét +1 more
TL;DR: A review of the role of zinc in the etiology of Alzheimer's disease can be found in this paper, where the authors discuss the interactions of zinc and copper with Abeta, a factor that facilitates disease processes.
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Cell–Matrix Interactions Improve β-Cell Survival and Insulin Secretion in Three-Dimensional Culture
TL;DR: It is demonstrated that specific, rationally designed extracellular environments promote isolated beta-cell survival and function and synergistic interactions are demonstrated.
References
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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
Journal Article
Cleavage of structural proteins during the assemble of the head of bacterio-phage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products as mentioned in this paper.
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Nucleotide sequence from the neurogenic locus Notch implies a gene product that shares homology with proteins containing EGF-like repeats
TL;DR: It is speculated that the Notch locus may be involved in a cell-cell interaction mechanism that is essential for the differentiation of the ectoderm into neural and epidermal precursors.
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Potential metal-binding domains in nucleic acid binding proteins.
TL;DR: Observations suggest numerous experiments are needed to determine whether metal-binding domains are present in proteins and, if present, what roles such domains play in the processes of nucleic acid binding and gene regulation.
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Molecular architecture of basement membranes.
TL;DR: A large heparan sulfate proteoglycan, important for charge‐dependent molecular sieving, is firmly anchored in the basement membrane and can bind itself through a core‐protein interaction to form dimers and oligomers and bind laminin and type IV collagen through its glycosaminoglycan chains.