Large offspring syndrome in cattle and sheep.
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Cites background from "Large offspring syndrome in cattle ..."
...Few embryos survive to birth, and many of the survivors die in the postnatal period or succumb prematurely to a variety of abnormalitie...
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2,212 citations
Cites background from "Large offspring syndrome in cattle ..."
...In addition, cloned animals frequently show abnormalities (placental and fetal overgrowth, and perinatal death...
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878 citations
Cites background from "Large offspring syndrome in cattle ..."
...After nuclear transfer or even exposure to in vitro environments by tissue culture, unusually large offspring have been born, and this has been referred to as “large offspring syndrome” (LOS) (Young et al. 1998)....
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...Direct evidence that overgrowth in ART offspring of animals may be linked to imprinting abnormalities came initially from studies showing that sheep affected with LOS that are derived from cultured embryos undergo LOI of the IGF2 receptor gene (Young et al. 2001), although this gene is not imprinted in humans....
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