Large scale comparison of global gene expression patterns in human and mouse
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Cites background from "Large scale comparison of global ge..."
...Mouse models are the bed stone of mechanistic studies of human genes and their role in different diseases due to conserved sequence, function and expression profiles of their orthologous genes (23,32-35)....
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"Large scale comparison of global ge..." refers methods in this paper
...The resulting 1,323 CEL files were pre-processed using Bioconductor’s RMA package [32] to create an integrated, normalized data matrix....
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"Large scale comparison of global ge..." refers background or result in this paper
...While studies suggested that orthologous genes do not share similar expression patterns [1-5], other groups reported the opposite observations [6-9]....
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...Alternatively, many other studies made use of species-specific arrays to identify coexpressed groups of orthologous genes [4-6,16,17]....
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"Large scale comparison of global ge..." refers methods in this paper
...PCA has been often used to study high-dimensional data generated by genome-wide gene expression studies [22-25]....
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