Large scale comparison of global gene expression patterns in human and mouse
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...While some reports show a high conservation in expression of orthologous genes (Zheng-Bradley et al., 2010), there are many examples of divergence of gene function, alternate splicing events and differences in copy number variants between mice and humans (Gharib and Robinson-Rechavi, 2011) (Table…...
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...While some reports show a high conservation in expression of orthologous genes (Zheng-Bradley et al., 2010), there are many examples of divergence of gene function, alternate splicing events and differences in copy number variants between mice and humans (Gharib and Robinson-Rechavi, 2011) (Table 1)....
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62 citations
Cites background or result from "Large scale comparison of global ge..."
...It is also consistent with findings from comparative expression studies of mice and humans showing that house-keeping genes were more highly expressed and were more conserved among species both in terms of their sequence and their expression [7]....
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...A comparative analysis of mouse and human showed a high level of conservation in the expression of orthologous genes, showing the stability of house-keeping genes and the variability of tissue specific genes [7]....
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References
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"Large scale comparison of global ge..." refers methods in this paper
...The resulting 1,323 CEL files were pre-processed using Bioconductor’s RMA package [32] to create an integrated, normalized data matrix....
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3,513 citations
"Large scale comparison of global ge..." refers background or result in this paper
...While studies suggested that orthologous genes do not share similar expression patterns [1-5], other groups reported the opposite observations [6-9]....
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...Alternatively, many other studies made use of species-specific arrays to identify coexpressed groups of orthologous genes [4-6,16,17]....
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2,683 citations
"Large scale comparison of global ge..." refers methods in this paper
...PCA has been often used to study high-dimensional data generated by genome-wide gene expression studies [22-25]....
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2,625 citations