Large-Scale Reorganization in the Somatosensory Cortex and Thalamus after Sensory Loss in Macaque Monkeys
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46 citations
Cites background from "Large-Scale Reorganization in the S..."
...However, a recent study in primate using a unilateral cervical spinal cord injury demonstrated reorganization in the thalamus that paralleled that of the cortex after 2 years (Jain et al., 2008)....
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44 citations
Cites background or result from "Large-Scale Reorganization in the S..."
...…Darian-Smith and Ciferri, 2006; Kaas et al., 2008; Qi et al., 2011) and has shown that the reactivation of area 3b, along with other cortical and subcortical regions (Jain et al., 1997, 2008), contribute significantly to the functional and behavioral recovery of the damaged sensorimotor functions....
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...Although the neuronal response properties characterized at the end of the 2–3 months recovery period are similar to previous findings (Jain et al., 1997, 1998, 2008), we identified here a dynamic shift of individual digit activation centers during this recovery period....
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...…(Flor et al., 1995, 1997; Mühlnickel et al., 1998; Karl et al., 2001; Muellbacher and Hallett, 2006; Fox 2009), although the neuronal mechanisms underlying plastic changes in the brain and behavioral recoveries remain unclear (for discussion, see Jain et al., 2008; Graziano and Jones, 2009)....
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...Additional details about surgical procedures can be found in previous publications from the laboratory (Jain et al., 1997, 2008; Qi et al., 2011)....
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41 citations
Cites background or result from "Large-Scale Reorganization in the S..."
...Similar results have been reported in other studies of monkeys after dorsal column lesions (2, 4, 5)....
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...When somatosensory inputs from the hand have been largely removed in monkeys by cutting ascending branches of cutaneous afferents in the dorsal column pathways of the spinal cord (2, 4, 5) or by selectively cutting the dorsal roots of peripheral nerves subserving a part of the hand (3), most of the territory of the representation of the hand in the contralateral primary somatosensory cortex (area 3b) initially fails to respond to touch on the hand....
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...The existence of both unresponsive sites and sites responsive to various locations on the hand have been reported in previous studies of the effects of spontaneous reactivation of hand cortex after dorsal column lesions in monkeys (2, 4, 5)....
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References
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"Large-Scale Reorganization in the S..." refers background in this paper
...A small expansion of the face inputs into the hand region of the cortex was seen long after hand or arm amputations (Flor et al., 1995; Florence and Kaas, 1995; Grüsser et al., 2004), or immediately after median and radial nerve injury or block (Silva et al....
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1,327 citations
"Large-Scale Reorganization in the S..." refers background in this paper
...…the cortical maps has been demonstrated in a variety of mammalian species after different kinds of deprivations including digit or limb amputations (Merzenich et al., 1984; Wall and Cusick, 1984; Calford and Tweedale, 1988; Turnbull and Rasmusson, 1991; Florence et al., 1998), nerve transections…...
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...Since then, reorganization of the cortical maps has been demonstrated in a variety of mammalian species after different kinds of deprivations including digit or limb amputations (Merzenich et al., 1984; Wall and Cusick, 1984; Calford and Tweedale, 1988; Turnbull and Rasmusson, 1991; Florence et al., 1998), nerve transections (Wall and Kaas, 1985; Garraghty and Kaas, 1991b), dorsal root transections (Pons et al....
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1,051 citations
"Large-Scale Reorganization in the S..." refers background or methods in this paper
...It is possible that this has not been reported before because the foot region of the cortex was not mapped previously (Pons et al., 1991; Jain et al., 1997)....
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...in macaque monkeys (Pons et al., 1991) and a comparable 5 mm...
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...After an extensive recovery period the boundaries of the face representation shift medially into the hand region by as much as 10 –14 mm in macaque monkeys (Pons et al., 1991) and a comparable 5 mm in smaller owl monkeys (Jain et al., 1997)....
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...Limits of plasticity in area 3b The maximal extent of shift in representational boundaries reported before this study is in the range of 10 –14 mm for macaque monkeys (Pons et al., 1991) and 5 mm for smaller brained owl monkeys (Jain et al....
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...In contrast, after transection of the dorsal roots of the spinal cord from C2 to T4, the deprived hand, arm, and occiput regions of area 3b come to respond to the inputs from the chin (Pons et al., 1991)....
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948 citations