Large-Scale Reorganization in the Somatosensory Cortex and Thalamus after Sensory Loss in Macaque Monkeys
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34 citations
Cites background from "Large-Scale Reorganization in the S..."
...But only few studies focused on thalamic spontaneous activity as well as the evoked responses that are expanded into the thalamic deafferented region (Gerke et al., 2003; Jain et al., 2008; Liang and Mendell, 2013)....
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34 citations
Cites background from "Large-Scale Reorganization in the S..."
...…above, the observed improvements are probably based on rapid changes in the receptive fields at different levels of the somatosensory system, e.g., in the somatosensory cortex as well as in the thalamus (Nicolelis et al., 1993; Weiss et al., 2004; Jain et al., 2008; Björkman et al., 2009)....
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..., in the somatosensory cortex as well as in the thalamus (Nicolelis et al., 1993; Weiss et al., 2004; Jain et al., 2008; Björkman et al., 2009)....
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33 citations
33 citations
Cites background from "Large-Scale Reorganization in the S..."
...Other studies reported massive expansion of the cortical face representation after lesion of the dorsal columns at levels varying from C3 to C7 (Jain et al., 1997; Jain et al., 2008)....
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...Two years after a spinal injury of this type, no clear cellular atrophy has been reported in the brainstem or thalamus (Cowan et al., 1970), and that was confirmed in the present study, but cortical reorganization is demonstrable (Merzenich et al., 1984; Jain et al., 2008)....
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..., 1970), and that was confirmed in the present study, but cortical reorganization is demonstrable (Merzenich et al., 1984; Jain et al., 2008)....
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32 citations
Cites background or result from "Large-Scale Reorganization in the S..."
...…al., 1997; Florence et al., 1998; Li et al., 2013), the section of peripheral nerve afferents as they travel in the dorsal columns of spinal cord (Jain et al., 1997, 1998, 2000, 2008; Weng et al., 2003; Graziano and Jones, 2009; Qi et al., 2011a), or spinal cord injury in rodents (Ghosh et al.,…...
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...We and others have also studied area 3b reorganization in macaque monkey (Pons et al., 1991; Florence and Kaas, 1995; Florence et al., 1998; Darian-Smith and Brown, 2000; Jain et al., 2008), where area 3b is hidden on the caudal bank of a deep central fissure, as in humans....
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...Such results have been reported in a number of studies, including those from owl monkeys, squirrel monkeys, marmosets, and macaque monkeys (Jain et al., 1997, 1998, 2008; Qi et al., 2011a; Bowes et al., 2012, 2013)....
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...…the area 1 representation of touch is restored in a somatotopic pattern that generally parallels that in area 3b, but it is less precise in detailed somatotopy, and the neuronal responses tend to be weaker in the reactivated regions (Merzenich et al., 1983a; Jain et al., 2008; Qi et al., 2011a)....
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References
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"Large-Scale Reorganization in the S..." refers background in this paper
...A small expansion of the face inputs into the hand region of the cortex was seen long after hand or arm amputations (Flor et al., 1995; Florence and Kaas, 1995; Grüsser et al., 2004), or immediately after median and radial nerve injury or block (Silva et al....
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1,327 citations
"Large-Scale Reorganization in the S..." refers background in this paper
...…the cortical maps has been demonstrated in a variety of mammalian species after different kinds of deprivations including digit or limb amputations (Merzenich et al., 1984; Wall and Cusick, 1984; Calford and Tweedale, 1988; Turnbull and Rasmusson, 1991; Florence et al., 1998), nerve transections…...
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...Since then, reorganization of the cortical maps has been demonstrated in a variety of mammalian species after different kinds of deprivations including digit or limb amputations (Merzenich et al., 1984; Wall and Cusick, 1984; Calford and Tweedale, 1988; Turnbull and Rasmusson, 1991; Florence et al., 1998), nerve transections (Wall and Kaas, 1985; Garraghty and Kaas, 1991b), dorsal root transections (Pons et al....
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1,051 citations
"Large-Scale Reorganization in the S..." refers background or methods in this paper
...It is possible that this has not been reported before because the foot region of the cortex was not mapped previously (Pons et al., 1991; Jain et al., 1997)....
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...in macaque monkeys (Pons et al., 1991) and a comparable 5 mm...
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...After an extensive recovery period the boundaries of the face representation shift medially into the hand region by as much as 10 –14 mm in macaque monkeys (Pons et al., 1991) and a comparable 5 mm in smaller owl monkeys (Jain et al., 1997)....
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...Limits of plasticity in area 3b The maximal extent of shift in representational boundaries reported before this study is in the range of 10 –14 mm for macaque monkeys (Pons et al., 1991) and 5 mm for smaller brained owl monkeys (Jain et al....
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...In contrast, after transection of the dorsal roots of the spinal cord from C2 to T4, the deprived hand, arm, and occiput regions of area 3b come to respond to the inputs from the chin (Pons et al., 1991)....
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948 citations