Large-Scale Reorganization in the Somatosensory Cortex and Thalamus after Sensory Loss in Macaque Monkeys
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Cites background from "Large-Scale Reorganization in the S..."
...However, a primate study using a unilateral cervical spinal cord injury demonstrated reorganization in the thalamus that paralleled in the cortex after 2 years (Jain et al. 2008)....
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31 citations
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Cites background from "Large-Scale Reorganization in the S..."
...These changes include the expansion of new facial connections into the deafferented hand region (in the primary somatosensory cortex [15] and the ventroposterior nucleus of the thalamus [16], spinal cord, and dorsal column nuclei [17]) as well as the transneuronal atrophy of deafferented structures [18]....
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30 citations
Cites background from "Large-Scale Reorganization in the S..."
...The somatotopic organization in area 3b is indicated: OC, oral cavity; Fa, face; H, hand; A, arm; O, occiput; T, trunk; L, leg; Ft, foot (adapted from Nelson et al., 1980; Jain et al., 2008)....
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...…its large size, functional importance in evaluating and processing food (Shepherd, 2012), expansion after spinal cord injury (Pons et al., 1991; Jain et al., 1997, 1998b, 2008; Fang et al., 2002), and role in coordinating movements of the tongue and jaw (Lin et al., 1993, 1994), little is…...
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...…Kaas, 1995) and deafferenting injuries of the peripheral nerves (Merzenich et al., 1983a,b; Garraghty and Kaas, 1991; Garraghty et al., 1994) and spinal cord (Pons et al., 1991; Jain et al., 1997, 1998b, 2008) can lead to changes in the responsiveness of the region of area 3b representing the hand....
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...Reorganization in the somatosensory cortex after such injuries often results in hand cortex becoming responsive to stimulation on the face (Merzenich et al., 1984; Pons et al., 1991; Florence and Kaas, 1995; Jain et al., 1997, 1998b, 2008; Manger et al., 1997)....
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...…allowed us to evaluate the possibility that intrinsic connections between hand and face representations in area 3b underlie the reactivation of hand cortex by inputs from the face after loss of sensory input from the hand (Pons et al., 1991; Jain et al., 1997, 1998b, 2008; Fang et al., 2002)....
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References
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"Large-Scale Reorganization in the S..." refers background in this paper
...A small expansion of the face inputs into the hand region of the cortex was seen long after hand or arm amputations (Flor et al., 1995; Florence and Kaas, 1995; Grüsser et al., 2004), or immediately after median and radial nerve injury or block (Silva et al....
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1,327 citations
"Large-Scale Reorganization in the S..." refers background in this paper
...…the cortical maps has been demonstrated in a variety of mammalian species after different kinds of deprivations including digit or limb amputations (Merzenich et al., 1984; Wall and Cusick, 1984; Calford and Tweedale, 1988; Turnbull and Rasmusson, 1991; Florence et al., 1998), nerve transections…...
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...Since then, reorganization of the cortical maps has been demonstrated in a variety of mammalian species after different kinds of deprivations including digit or limb amputations (Merzenich et al., 1984; Wall and Cusick, 1984; Calford and Tweedale, 1988; Turnbull and Rasmusson, 1991; Florence et al., 1998), nerve transections (Wall and Kaas, 1985; Garraghty and Kaas, 1991b), dorsal root transections (Pons et al....
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1,051 citations
"Large-Scale Reorganization in the S..." refers background or methods in this paper
...It is possible that this has not been reported before because the foot region of the cortex was not mapped previously (Pons et al., 1991; Jain et al., 1997)....
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...in macaque monkeys (Pons et al., 1991) and a comparable 5 mm...
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...After an extensive recovery period the boundaries of the face representation shift medially into the hand region by as much as 10 –14 mm in macaque monkeys (Pons et al., 1991) and a comparable 5 mm in smaller owl monkeys (Jain et al., 1997)....
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...Limits of plasticity in area 3b The maximal extent of shift in representational boundaries reported before this study is in the range of 10 –14 mm for macaque monkeys (Pons et al., 1991) and 5 mm for smaller brained owl monkeys (Jain et al....
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...In contrast, after transection of the dorsal roots of the spinal cord from C2 to T4, the deprived hand, arm, and occiput regions of area 3b come to respond to the inputs from the chin (Pons et al., 1991)....
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948 citations