Laser-induced choroidal neovascularization model to study age-related macular degeneration in mice.
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Cites methods from "Laser-induced choroidal neovascular..."
...male mice according to a previously described method (72) with some...
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Cites background or methods from "Laser-induced choroidal neovascular..."
...Briefly, laser photocoagulation results in the rupture of Bruch’s membrane, leading to the ingrowth of immature leaky blood vessels into the outer avascular retina (103)....
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...We used the laser-induced choroidal neovascularization (CNV) mouse model that mimics features of exudative AMD to test this hypothesis (103)....
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...Briefly, laser photocoagulation results in the rupture of the Bruch’s membrane, leading to the ingrowth of immature leaky blood vessels from the choroid to the subretinal space (103)....
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171 citations
Cites background from "Laser-induced choroidal neovascular..."
...In the laser photocoagulation animal model, known to induce choroidal neovascularization [147], the increased productions of intracellular adhesion molecule 1 (ICAM-1) and IL-6 were prevented by administration of astaxanthin, known by its antioxidative and anti-inflammatory properties [148], reinforcing the role of the inflammatory response in the disease....
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