Laser Speckle Contrast Imaging for Perfusion Monitoring in Burn Tissue Phantoms
01 Jan 2011-pp 443-446
TL;DR: A non invasive Laser speckle contrast imaging (LSCI) system is presented here for monitoring different flow conditions in a burn layer simulated capillary phantom.
Abstract: Modeling and monitoring of blood perfusion in burn skin has been presented in this study. A non invasive Laser speckle contrast imaging (LSCI) system is presented here for monitoring different flow conditions in a burn layer simulated capillary phantom. Speckle contrast variations with respect to changes in burn depth and blood perfusion rate have been studied in this work.
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TL;DR: A noninvasive, noncontact and whole field laser speckle contrast imaging (LSCI) technique has been described in this paper which is used to assess the changes in blood flow in diabetic ulcer affected areas of the foot.
Abstract: Measuring microcirculatory tissue blood perfusion is of interest for both clinicians and researchers in a wide range of applications and can provide essential information of the progress of treatment of certain diseases which causes either an increased or decreased blood flow. Diabetic ulcer associated with alterations in tissue blood flow is the most common cause of non-traumatic lower extremity amputations. A technique which can detect the onset of ulcer and provide essential information on the progress of the treatment of ulcer would be of great help to the clinicians. A noninvasive, noncontact and whole field laser speckle contrast imaging (LSCI) technique has been described in this paper which is used to assess the changes in blood flow in diabetic ulcer affected areas of the foot. The blood flow assessment at the wound site can provide critical information on the efficiency and progress of the treatment given to the diabetic ulcer subjects. The technique may also potentially fulfill a significant need in diabetic foot ulcer screening and management.
13 citations
TL;DR: In this paper, the authors compared full field laser Doppler imaging (LDI) and single exposure laser speckle contrast imaging (LSCI) using a novel instrument which can concurrently image blood flow using both LDI and LSCI signal processing.
11 citations
Cites background from "Laser Speckle Contrast Imaging for ..."
...They are both useful as they can non-invasively obtain images of blood flow for a range of applications such as burn depth assessment [1], [2], wound healing [3], ophthalmology [4], [5], cardiac activity analysis [6], [7] and studies of stimulant reactions of cortical activity [8-10]....
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TL;DR: Perfusion values were calculated using two evaluation models, while changing the dynamic/static scattering ratio of monitored skin and tissue phantoms, and were strongly affected by the significant increase of static contribution.
Abstract: Static scattering is detrimental to the accuracy of laser speckle
contrast analysis (LASCA) measurements on skin when, instead of percentile
change monitoring, absolute perfusion values are needed, e.g., for tissue
injury examination. Perfusion values were calculated using two evaluation
models, while changing the dynamic/static scattering ratio of monitored
skin and tissue phantoms. Results were strongly affected by the
significant increase of static contribution. Measurements on a modified
tissue phantom showed that the changes in the measured perfusion values
were mostly caused by the mixed scattering, which was omitted by the
tested models. Dynamic ratio values obtained by multi-exposure LASCA could
be used for perfusion data correction.
1 citations
References
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TL;DR: The known optical properties (absorption, scattering, total attenuation, effective attenuation and/or anisotropy coefficients) of various biological tissues at a variety of wavelengths are reviewed in this article.
Abstract: The known optical properties (absorption, scattering, total attenuation, effective attenuation, and/or anisotropy coefficients) of various biological tissues at a variety of wavelengths are reviewed. The theoretical foundations for most experimental approaches are outlined. Relations between Kubelka-Munk parameters and transport coefficients are listed. The optical properties of aorta, liver, and muscle at 633 nm are discussed in detail. An extensive bibliography is provided. >
2,858 citations
TL;DR: In this paper, the distribution of scale sizes in a speckle pattern (i.e., the Wiener spectrum) is investigated from a physical point of view, and it is shown that adding M uncorrelated speckles on an intensity basis can reduce the contrast by 1/√M.
Abstract: A speckle pattern formed in polarized monochromatic light may be regarded as resulting from a classical random walk in the complex plane. The resulting irradiance fluctuations obey negative exponential statistics, with ratio of standard deviation to mean (i.e., contrast) of unity. Reduction of this contrast, or smoothing of the speckle, requires diversity in polarization, space, frequency, or time. Addition of M uncorrelated speckle patterns on an intensity basis can reduce the contrast by 1/√M. However, addition of speckle patterns on a complex amplitude basis provides no reduction of contrast. The distribution of scale sizes in a speckle pattern (i.e., the Wiener spectrum) is investigated from a physical point of view.
2,093 citations
Book•
01 Jan 1975
TL;DR: Dainty et al. as mentioned in this paper described statistical properties of laser speckle patterns and proposed a method to reduce the number of sparseness of the laser beam in Partially Coherent Light (PCL).
Abstract: Contents: Dainty, J. C.: Introduction. - Goodman, J. W.: Statistical Properties of Laser Speckle Patterns. - Parry, G.: Speckle Patterns in Partially Coherent Light. - McKechnie, T. S.: Speckle Reduction. - Francon, M.: Information Processing Using Speckle Patterns. - Ennos, A. E.: Speckle Interferometry. - Dainty, J. C.: Stellar Speckle Interferometry. - Dainty, J. C.: Recent Developments. - Subject Index.
1,254 citations
TL;DR: Using this method, dynamic images of the relative CBF changes during focal cerebral ischemia and cortical spreading depression were obtained along with electrophysiologic recordings and validated through direct comparison with conventional laser-Doppler measurements.
Abstract: A method for dynamic, high-resolution cerebral blood flow (CBF) imaging is presented in this article. By illuminating the cortex with laser light and imaging the resulting speckle pattern, relative CBF images with tens of microns spatial and millisecond temporal resolution are obtained. The regional CBF changes measured with the speckle technique are validated through direct comparison with conventional laser-Doppler measurements. Using this method, dynamic images of the relative CBF changes during focal cerebral ischemia and cortical spreading depression were obtained along with electrophysiologic recordings. Upon middle cerebral artery (MCA) occlusion, the speckle technique yielded high-resolution images of the residual CBF gradient encompassing the ischemic core, penumbra, oligemic, and normally perfused tissues over a 6 × 4 mm cortical area. Successive speckle images demonstrated a further decrease in residual CBF indicating an expansion of the ischemic zone with finely delineated borders. Dynamic CBF...
843 citations
TL;DR: A new noninvasive technique for monitoring capillary blood flow based on the phenomenon of time-varying laser speckle, which provides a velocity map of the area of interest in real time without the need for scanning.
Abstract: A new noninvasive technique for monitoring capillary blood flow has been developed. Based on the phenomenon
of time-varying laser speckle, it is a digital version of single-exposure speckle photography. It
provides a velocity map of the area of interest in real time without the need for scanning. The results of some initial experiments on volunteers are presented.
669 citations