Late-life depression, mild cognitive impairment, and dementia.
Edo Richard,Christiane Reitz,Lawrence H. Honig,Nicole Schupf,Ming X. Tang,Jennifer J. Manly,Richard Mayeux,Devangere P. Devanand,José A. Luchsinger +8 more
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TLDR
The association of depression with prevalent MCI and with progression from MCI to dementia, but not with incident MCI, suggests that depression accompanies cognitive impairment but does not precede it.Abstract:
Objective To evaluate the association of late-life depression with mild cognitive impairment (MCI) and dementia in a multiethnic community cohort. Design and Setting A cohort study was conducted in Northern Manhattan, New York, New York. Participants A total of 2160 community-dwelling Medicare recipients aged 65 years or older were included in the study. Methods Depression was assessed using the 10-item version of the Center for Epidemiological Studies Depression scale (CES-D) and defined by a CES-D score of 4 or more. We used logistic regression for cross-sectional association analyses and proportional hazards regression for longitudinal analyses. Main Outcome Measures Mild cognitive impairment dementia, and progression from MCI to dementia were the main outcome measures. We also used subcategories of MCI (amnestic and nonamnestic), and dementia (probable Alzheimer disease and vascular dementia, including possible Alzheimer disease with stroke). Results Baseline depression was associated with prevalent MCI (odds ratio, 1.4; 95% CI, 1.1-1.9) and dementia (2.2; 1.6-3.1). Baseline depression was associated with an increased risk of incident dementia (hazard ratio [HR], 1.7; 95% CI, 1.2-2.3) but not with incident MCI (0.9; 0.7-1.2). Persons with MCI and coexisting depression at baseline had a higher risk of progression to dementia (HR, 2.0; 95% CI, 1.2-3.4), especially vascular dementia (4.3; 1.1-17.0), but not Alzheimer disease (1.9; 1.0-3.6). Conclusion The association of depression with prevalent MCI and with progression from MCI to dementia, but not with incident MCI, suggests that depression accompanies cognitive impairment but does not precede it.read more
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Cumulative use of strong anticholinergics and incident dementia: a prospective cohort study.
Shelly L. Gray,Melissa L. Anderson,Sascha Dublin,Joseph T. Hanlon,Rebecca A. Hubbard,Rod L. Walker,Onchee Yu,Paul K. Crane,Eric B. Larson +8 more
TL;DR: In this paper, the authors examined whether cumulative anticholinergic use is associated with a higher risk for incident dementia and found a 10-year cumulative dose-response relationship was observed for dementia and Alzheimer disease.
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Computerized Cognitive Training in Older Adults With Mild Cognitive Impairment or Dementia: A Systematic Review and Meta-Analysis
Nicole Hill,Loren Mowszowski,Sharon L. Naismith,Verity L. Chadwick,Michael Valenzuela,Amit Lampit +5 more
TL;DR: This intervention warrants longer-term and larger-scale trials to examine effects on conversion to dementia, as evidence for efficacy in people with dementia is weak and limited to trials of immersive technologies.
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Sex differences in cognitive impairment and Alzheimer's disease
Rena Li,Meharvan Singh +1 more
TL;DR: This review draws on epidemiological, translational, clinical, and basic science studies to assess the impact of sex differences in cognitive function from young to old, and examines the effects of sex hormone treatments on Alzheimer's disease in men and women.
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Depression and dementia: Cause, consequence or coincidence?
Sophia Bennett,Alan J. Thomas +1 more
TL;DR: Overall there is convincing evidence to support both the notion that early life depression can act as a risk factor for later life dementia, and that laterlife depression can be seen as a prodrome to dementia.
Journal ArticleDOI
Prevalence of Depression in Patients With Mild Cognitive Impairment: A Systematic Review and Meta-analysis.
Zahinoor Ismail,Heba Elbayoumi,Corinne E. Fischer,David B. Hogan,Colleen Millikin,Tom A. Schweizer,Moyra E. Mortby,Eric E. Smith,Scott B. Patten,Kirsten M. Fiest +9 more
TL;DR: The method used to diagnose depression did not significantly influence the prevalence estimate, nor did the criteria used for MCI diagnosis or MCI subtype, and a contributor to heterogeneity in the reported literature is the source of the sample, with greater depression burden prevalent in clinic-based samples.
References
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Journal ArticleDOI
The CES-D Scale: A Self-Report Depression Scale for Research in the General Population
TL;DR: The CES-D scale as discussed by the authors is a short self-report scale designed to measure depressive symptomatology in the general population, which has been used in household interview surveys and in psychiatric settings.
Journal ArticleDOI
Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
TL;DR: The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.
Journal ArticleDOI
Mild Cognitive Impairment: Clinical Characterization and Outcome
Ronald C. Petersen,Glenn E. Smith,Stephen C. Waring,Robert J. Ivnik,Eric G. Tangalos,Emre Kokmen +5 more
TL;DR: Patients who meet the criteria for MCI can be differentiated from healthy control subjects and those with very mild AD, and appear to constitute a clinical entity that can be characterized for treatment interventions.
Journal ArticleDOI
Vascular dementia Diagnostic criteria for research studies: Report of the NINDS‐AIREN International Workshop*
Gustavo C. Román,Thomas K. Tatemichi,T. Erkinjuntti,Jeffrey L. Cummings,Joseph C. Masdeu,J. H. Garcia,L. Amaducci,J. M. Orgogozo,A. Brun,Albert Hofman,D. M. Moody,M. D. O’Brien,T. Yamaguchi,Jordan Grafman,B. P. Drayer,D. A. Bennett,Marc Fisher,J. Ogata,E. Kokmen,F. Bermejo,Philip A. Wolf,P. B. Gorelick,K. L. Bick,A. K. Pajeau,M. A. Bell,Charles DeCarli,A. Culebras,Amos D. Korczyn,J. Bogousslavsky,A. Hartmann,P. Scheinberg +30 more
TL;DR: These criteria for the diagnosis of vascular dementia are intended as a guide for case definition in neuroepidemiologic studies, stratified by levels of certainty (definite, probable, and possible).
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