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Late-stage fluorination: fancy novelty or useful tool?
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TLDR
It is outlined how an improved understanding of the bonding interactions of fluoride could lead to a new class of mild fluorinating reagents and a range of functional-group-tolerant reactions.Abstract:
Charming fluorine: This Essay examines the recent surge in late-stage fluorination reactions and outlines challenges that need to be overcome to increase the impact of modern fluorination methods on the synthesis of complex organofluorine compounds. It is outlined how an improved understanding of the bonding interactions of fluoride could lead to a new class of mild fluorinating reagents and a range of functional-group-tolerant reactions.read more
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Electrochemical strategies for C-H functionalization and C-N bond formation.
TL;DR: This review provides an overview on the use of anodic electrochemical methods for expediting the development of carbon-hydrogen functionalization and carbon-nitrogen bond formation strategies and aims to provide inspiration for future synthetic applications in the field of electrosynthesis.
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Visible-Light-Induced Decarboxylative Functionalization of Carboxylic Acids and Their Derivatives
TL;DR: Recent advances in visible-light-induced radical decarboxylative functionalization of carboxylic acids and their derivatives are discussed herein.
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Key Green Chemistry research areas from a pharmaceutical manufacturers’ perspective revisited
Marian C. Bryan,Peter J. Dunn,David Entwistle,Fabrice Gallou,Stefan G. Koenig,John D. Hayler,Matthew R. Hickey,Shaun Hughes,Michael E. Kopach,Gerard Moine,Paul G. Richardson,Frank Roschangar,Alan Steven,Franz J. Weiberth +13 more
TL;DR: In 2007, the members of the ACS Green Chemistry Institute® Pharmaceutical Roundtable assembled a list of key green chemistry research areas to both identify transformations that would benefit from improvements in process greenness and to encourage academic research to this end as mentioned in this paper.
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Decarboxylative Fluorination of Aliphatic Carboxylic Acids via Photoredox Catalysis
TL;DR: Experimental evidence indicates that an oxidative quenching pathway is operable in this operationally simple, redox-neutral fluorination method, which is amenable to a wide variety of carboxylic acids.
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Visible Light Photocatalysis: Applications and New Disconnections in the Synthesis of Pharmaceutical Agents
TL;DR: This review focuses on the application of photoredox catalysis to arrive at known pharmaceutically active compounds and the growing synergy with other modes of catalysis, such as nickel/photoredox dual catalysis.
References
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Fluorine in medicinal chemistry.
TL;DR: This tutorial review provides a sampling of renowned fluorinated drugs and their mode of action with a discussion clarifying the role and impact of fluorine substitution on drug potency.
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Introduction of Fluorine and Fluorine-Containing Functional Groups
TL;DR: This Review gives a brief summary of conventional fluorination reactions, including those reactions that introduce fluorinated functional groups, and focuses on modern developments in the field.
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Catalysis for fluorination and trifluoromethylation
TL;DR: Reactions to make organofluorides that have emerged within the past few years are discussed and which exemplify how to overcome some of the intricate challenges associated with fluorination.
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