Letter to the editor: Effects of mercuric chloride treatment in vitro on the antioxidant defence system and activation of human blood platelets
01 Aug 1988-International Journal of Environmental Studies (Informa UK Limited)-Vol. 31, Iss: 4, pp 313-313
About: This article is published in International Journal of Environmental Studies.The article was published on 1988-08-01. It has received None citations till now.
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TL;DR: Observations suggest that an SH-containing substrate affecting the adhesion reaction is probably located beneath the plasma membrane of the platelet, which suggests that a free or intact sulfhydryl group is involved in platelet adhesion to connective tissue.
Abstract: SummaryThe studies reported present evidence that a free or intact sulfhydryl group is involved in platelet adhesion to connective tissue. Exposure of platelets to the readily penetrating sulfhydryl inhibitors NEM or PHMB immediately blocks their ability to adhere to connective tissue. PHMBS, which penetrates platelet membrane very slowly, produces an inhibitory effect only after prolonged incubation. These observations suggest that an SH-containing substrate affecting the adhesion reaction is probably located beneath the plasma membrane of the platelet.
23 citations
Journal Article•
7 citations
TL;DR: NEM, but not membrane-active drugs, inhibits the release of adenine nucleotides from washed, resuspended platelets, which suggests that the two types of inhibitor exert their effects on platelets through somewhat different mechanisms.
2 citations