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Licochalcone A inhibits proliferation and promotes apoptosis of colon cancer cell by targeting programmed cell death-ligand 1 via the NF-κB and Ras/Raf/MEK pathways.
Xueshuang Liu,Yue Xing,Ming-Yue Li,Zhi Hong Zhang,Jing Ying Wang,MyongHak Ri,Cheng-Hua Jin,Guang Hua Xu,Lian Xun Piao,Honglan Jin,Hongxiang Zuo,Juan Ma,Xuejun Jin +12 more
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Zhang et al. as mentioned in this paper explored the anti-tumor activity and potential mechanism of licochalcone A in vitro and in vivo, and found that licochalancone A suppressed the expression of PD-L1 by blocking the interaction between p65 and Ras.About:
This article is published in Journal of Ethnopharmacology.The article was published on 2021-03-04. It has received 27 citations till now. The article focuses on the topics: Licochalcone A & Cytotoxic T cell.read more
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Development of natural products for anti-PD-1/PD-L1 immunotherapy against cancer.
Myong Hak Ri,Juan Ma,Xuejun Jin +2 more
TL;DR: In this article, the authors summarize natural products, raw extracts, and traditional medicines with pharmacological effects associated with the PD-1/PD-L1 axis, particularly PD-L 1.
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Network Pharmacology and Molecular Docking Study of the Chinese Miao Medicine Sidaxue in the Treatment of Rheumatoid Arthritis
TL;DR: Wang et al. as discussed by the authors investigated the molecular mechanisms of compound sidaxue (SX), a prescription of Chinese Miao medicine, in treating rheumatoid arthritis (RA) using network pharmacology and in vivo experimental approaches.
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Natural Products and their Derivatives as Immune Check Point Inhibitors: Targeting Cytokine/Chemokine Signalling in Cancer.
TL;DR: In this paper , a review summarises cytokine/chemokine signalling, types of cancer immunotherapy and the herbal medicine-derived natural products targeting cytokine and immune checkpoints.
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Anti-Inflammatory Effect of Licochalcone A via Regulation of ORAI1 and K+ Channels in T-Lymphocytes
TL;DR: Zhang et al. as discussed by the authors investigated whether licochalcone A inhibits ORAI1 and K+ channels in T-lymphocytes and found that it suppressed all three channels (ORAI1, Kv1.3, and KCa3) in a concentration-dependent matter.
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Immunometabolism modulation, a new trick of edible and medicinal plants in cancer treatment
TL;DR: Wang et al. as mentioned in this paper focused on the metabolic influence in immunocytes and tumor microenvironment, including immune response, immunosuppressive factors and cancer cells, discussing the immunometabolic potential of EMPs in cancer treatment.
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