Life and Death of Neurons in the Aging Brain
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...Although early studies postulated this atrophy to be due to neurodegeneration, several recent studies suggest that neuron number is relatively preserved in the healthy aging brain of both humans and nonhuman primates (Morrison and Hof, 1997; Peters et al., 1998), although alterations in neuronal morphology are evident....
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...One final point is that, while the present study does not specify the underlying mechanisms of cortical thinning, current literature based on histology suggests that such changes are unlikely to originate from neuronal death, as careful post-mortem studies have found relatively comparable neuronal counts between older and younger subjects (for reviews, see Dani, 1997; Morrison and Hof, 1997), a finding that is supported by work with nonhuman primates (Peters et al....
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...…are unlikely to originate from neuronal death, as careful post-mortem studies have found relatively comparable neuronal counts between older and younger subjects (for reviews, see Dani, 1997; Morrison and Hof, 1997), a finding that is supported by work with nonhuman primates (Peters et al., 1998)....
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...…postulated this atrophy to be due to neurodegeneration, several recent studies suggest that neuron number is relatively preserved in the healthy aging brain of both humans and nonhuman primates (Morrison and Hof, 1997; Peters et al., 1998), although alterations in neuronal morphology are evident....
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...Rather, cellular shrinkage and reduction in dendritic arborization are more likely to account for cortical thinning (Morrison and Hof, 1997)....
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