Lifespan and reproduction in Drosophila: New insights from nutritional geometry
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732 citations
Cites background or result from "Lifespan and reproduction in Drosop..."
...The results are consistent with recent reports in invertebrates showing that the ratio of protein to carbohydrate in the diet influences lifespan (Lee et al., 2008; Piper et al., 2011)....
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...…the susceptibility to obesity and metabolic disease, immune function, and resistance to infectious diseases (Blumfield et al., 2012; Gosby et al., 2011; Huang et al., 2013; Lee et al., 2008; Mayntz et al., 2009; Piper et al., 2011; Ponton et al., 2011; Simpson and Raubenheimer, 2009, 2012)....
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...In particular, it has emerged that the balance of protein to nonprotein energy in the diet is especially significant, influencing total energy intake, growth and development, body composition, reproduction, aging, gut microbial ecology, the susceptibility to obesity and metabolic disease, immune function, and resistance to infectious diseases (Blumfield et al., 2012; Gosby et al., 2011; Huang et al., 2013; Lee et al., 2008; Mayntz et al., 2009; Piper et al., 2011; Ponton et al., 2011; Simpson and Raubenheimer, 2009, 2012)....
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...The development of the Geometric Framework for nutrition (GF) now provides a platform for taming this complexity (Lee et al., 2008; Mayntz et al., 2005; Piper et al., 2011; Simpson and Raubenheimer, 2009, 2012)....
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...Thus, we relate macronutrient intakes to longevity, in particular testing the extent to which lifespan in ad libitum-fed mice is determined by calorie intake per se or by the balance of protein to carbohydrate, as recently proposed from GF studies of insects (Fanson et al., 2009; Lee et al., 2008)....
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680 citations
656 citations
615 citations
Cites background or result from "Lifespan and reproduction in Drosop..."
...to carbohydrate that correspond to the longest lifespans differ from the ratios that correspond to highest reproductive success (Lee et al. 2008; Maklakov et al. 2008),...
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...Yet, recent studies in Drosophila (Mair et al. 2005; Lee et al. 2008; Skorupa et al. 2008) and Teleogryllus crickets (Maklakov et al. 2008) have clearly indicated that in these systems, it is nutrient, rather than caloric, restriction that plays the major role in modulating lifespan....
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...Two complementary studies experimentally increased the costs of reproduction in female Drosophila melanogaster by stimulating egg production through supplementation with either yeast (Wang et al. 2001) or a juvenile hormone analogue— methoprene (Salmon et al. 2001)....
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...Yet, recent studies in Drosophila (Mair et al. 2005; Lee et al. 2008; Skorupa et al. 2008) and Teleogryllus crickets (Maklakov et al....
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...For instance, in both species, the ratios of protein to carbohydrate that correspond to the longest lifespans differ from the ratios that correspond to highest reproductive success (Lee et al. 2008; Maklakov et al. 2008), consistent with the idea that a trade-off exists between lifespan and fitness....
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469 citations
References
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1,205 citations
"Lifespan and reproduction in Drosop..." refers background in this paper
..., TOR) pathways (30), and damage to organs arising from nitrogenous breakdown products....
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954 citations
"Lifespan and reproduction in Drosop..." refers background in this paper
...It is widely held that the life-extending effects of dietary restriction (DR) are due to caloric restriction (CR) (1, 8, 9), but recently this view has been challenged by experiments suggesting that specific nutrients (proteins and certain amino acids) rather than energy are responsible (10–12)....
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647 citations
"Lifespan and reproduction in Drosop..." refers background in this paper
...There is growing interest in the relationship between dietary restriction and quality and length of life in humans, although experimental data are lacking and difficult to obtain (7)....
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